ArticleThe Journal of infectious diseases2015
Norovirus Infection and Disease in an Ecuadorian Birth Cohort: Association of Certain Norovirus Genotypes With Host FUT2 Secretor Status.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed, 4 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Global prevalence of norovirus gastroenteritis after emergence of the GII.4 Sydney 2012 variant: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Population-Level Human Secretor Status Is Associated With Genogroup 2 Type 4 Norovirus Predominance.The Journal of infectious diseases · 2020Pooled it
- Birth Cohort Studies Assessing Norovirus Infection and Immunity in Young Children: A Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Pooled it
- Host Genetic Susceptibility to Enteric Viruses: A Systematic Review and Metaanalysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Pooled it
- Symptomatic and Asymptomatic Norovirus Infections in Early Life; the PREVAIL Cohort, 2017-2020.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Enteric Viral Pathogens in Infants in the United States: 2017-2020.Pediatrics · 2026Article
- Estimating wastewater concentrations of norovirus and rotavirus from global data on community-level infection prevalence and viral shedding.Journal of water and health · 2026Article
- The saga to monitor and control norovirus: the rise of GII.17.The Journal of general virology · 2025Review
- Non-Secretor Status Due toMicroorganisms · 2025Article
- Incidence of Norovirus-Associated Acute Gastroenteritis across Age Groups in a Peruvian Andean Community.The American journal of tropical medicine and hygiene · 2025Article
- Norovirus-associated diarrhea and asymptomatic infection in children aged under 4 years: a community-cohort study in the Philippines.IJID regions · 2025Article
- A narrative review of norovirus epidemiology, biology, and challenges to vaccine development.NPJ vaccines · 2024Review
- Norovirus Disease Among Children <5 Years in 3 Sub-Saharan African Countries: Findings From the Vaccine Impact on Diarrhea in Africa (VIDA) Study, 2015-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Intestinal Norovirus Binding Patterns in Nonsecretor Individuals.Journal of virology · 2022Article
- Article
- Association of Secretor Status and Recent Norovirus Infection With Gut Microbiome Diversity Metrics in a Veterans Affairs Population.Open forum infectious diseases · 2022Article
- Secretor Status Strongly Influences the Incidence of Symptomatic Norovirus Infection in a Genotype-Dependent Manner in a Nicaraguan Birth Cohort.The Journal of infectious diseases · 2022Article
- Fucosyltransferase 2: A Genetic Risk Factor for Intestinal Diseases.Frontiers in microbiology · 2022Review
- Fucoidan and Derived Oligo-Fucoses: Structural Features with Relevance in Competitive Inhibition of Gastrointestinal Norovirus Binding.Marine drugs · 2021Article
- Glycan Recognition in Human Norovirus Infections.Viruses · 2021Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundAlthough norovirus is the most common cause of gastroenteritis, there are few data on the community incidence of infection/disease or the patterns of acquired immunity or innate resistance to norovirus.
methodsWe followed a community-based birth cohort of 194 children in Ecuador with the aim to estimate (1) the incidence of norovirus gastroenteritis from birth to age 3 years, (2) the protective effect of norovirus infection against subsequent infection/disease, and (3) the association of infection and disease with FUT2 secretor status.
resultsOver the 3-year period, we detected a mean of 2.26 diarrheal episodes per child (range, 0-12 episodes). Norovirus was detected in 260 samples (18%) but was not found more frequently in diarrheal samples (79 of 438 [18%]), compared with diarrhea-free samples (181 of 1016 [18%]; P = .919). A total of 66% of children had at least 1 norovirus infection during the first 3 years of life, and 40% of children had 2 infections. Previous norovirus infections were not associated with the risk of subsequent infection. All genogroup II, genotype 4 (GII.4) infections were among secretor-positive children (P < .001), but higher rates of non-GII.4 infections were found in secretor-negative children (relative risk, 0.56; P = .029).
conclusionsGII.4 infections were uniquely detected in secretor-positive children, while non-GII.4 infections were more often found in secretor-negative children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.