Evidence map›Paper›PMID 25505068›Full record

ArticleJournal of virology2015

Characterization of novel transcripts of human papillomavirus type 16 using cap analysis gene expression technology.

Ayumi Taguchi, Kazunori Nagasaka, Kei Kawana, Kosuke Hashimoto, Rika Kusumoto-Matsuo, Charles Plessy, Miranda Thomas, Hiroe Nakamura, Alessandro Bonetti, Katsutoshi Oda and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Global cis-regulatory landscape of double-stranded DNA viruses.bioRxiv : the preprint server for biology · 2025
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ayumi TaguchiDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kazunori NagasakaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan nagasakak-tky@umin.ac.jp kkawana-tky@umin.org.
Kei KawanaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan nagasakak-tky@umin.ac.jp kkawana-tky@umin.org.
Kosuke HashimotoRIKEN Center for Life Science Technologies, Division of Genomic Technologies, Yokohama, Japan.
Rika Kusumoto-MatsuoPathogen Genomic Center, National Institute of Infectious Diseases, Tokyo, Japan.
Charles PlessyRIKEN Center for Life Science Technologies, Division of Genomic Technologies, Yokohama, Japan.
Miranda ThomasInternational Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Hiroe NakamuraDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Alessandro BonettiRIKEN Center for Life Science Technologies, Division of Genomic Technologies, Yokohama, Japan.
Katsutoshi OdaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Iwao KukimotoPathogen Genomic Center, National Institute of Infectious Diseases, Tokyo, Japan.
Piero CarninciRIKEN Center for Life Science Technologies, Division of Genomic Technologies, Yokohama, Japan.
Lawrence BanksInternational Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Yutaka OsugaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Tomoyuki FujiiDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have performed cap-analysis gene expression (CAGE) sequencing to identify the regulatory networks that orchestrate genome-wide transcription in human papillomavirus type 16 (HPV16)-positive cervical cell lines of different grades: W12E, SiHa, and CaSki. Additionally, a cervical intraepithelial neoplasia grade 1 (CIN1) lesion was assessed for identifying the transcriptome expression profile. Here we have precisely identified a novel antisense noncoding viral transcript in HPV16. In conclusion, CAGE sequencing should pave the way for understanding a diversity of viral transcript expression.

Indexed as

Gene Expression ProfilingGene Expression Regulation, ViralFemaleHuman papillomavirus 16HumansMolecular BiologyRNA, AntisenseRNA, UntranslatedRNA, ViralUterine Cervical NeoplasmsRNA, AntisenseRNA, UntranslatedRNA, Viral

Identifiers

PMID25505068
PMCPMC4338893

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.