ArticleHuman brain mapping2015
Striatal shape abnormalities as novel neurodevelopmental endophenotypes in schizophrenia: a longitudinal study.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.Human brain mapping · 2022Pooled it
- Morphological and anatomical variations in subcortical anatomy between humans and chimpanzees associated with heritability patterns related to human behavioral traits.Communications biology · 2026Article
- Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies.Brain sciences · 2025Review
- The striatal compartments, striosome and matrix, are embedded in largely distinct resting-state functional networks.Frontiers in neural circuits · 2025Article
- A self-supervised learning framework for discovering cortical folding patterns under genetic influence: Application to the Anterior Cingulate Cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Subcortical shape in pediatric and adult obsessive-compulsive disorder.Depression and anxiety · 2022Article
- Longitudinal changes of deep gray matter shape in multiple sclerosis.NeuroImage. Clinical · 2022Article
- Neuroimaging Markers of Resiliency in Youth at Clinical High Risk for Psychosis: A Qualitative Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.Journal of psychiatry & neuroscience : JPN · 2020Article
- The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Characterizing the Subcortical Structures in Youth with Congenital Heart Disease.AJNR. American journal of neuroradiology · 2020Article
- Large-scale analyses of the relationship between sex, age and intelligence quotient heterogeneity and cortical morphometry in autism spectrum disorder.Molecular psychiatry · 2020Article
- Interactive effects of age and recent substance use on striatal shape morphology at substance use disorder treatment entry.Drug and alcohol dependence · 2020Article
- Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.NeuroImage. Clinical · 2020Article
- Generalizability of machine learning for classification of schizophrenia based on resting-state functional MRI data.Human brain mapping · 2020Article
- MR-based age-related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan.Human brain mapping · 2019Article
- Subcortical Shape Abnormalities in Bulimia Nervosa.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease.Human brain mapping · 2019Article
- Developmentally divergent sexual dimorphism in the cortico-striatal-thalamic-cortical psychosis risk pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Administration of memantine reverses behavioral, histological, and electrophysiological abnormalities in rats subjected to early maternal deprivation.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
There are varying, often conflicting, reports with respect to altered striatal volume and morphometry in the major psychoses due to the influences of antipsychotic medications on striatal volume. Thus, disassociating disease effects from those of medication become exceedingly difficult. For the first time, using a longitudinally studied sample of structural magnetic resonance images from patients with childhood onset schizophrenia (COS; neurobiologically contiguous with the adult onset form of schizophrenia), their nonpsychotic siblings (COSSIBs), and novel shape mapping algorithms that are volume independent, we report the familial contribution of striatal morphology in schizophrenia. The results of our volumetric analyses demonstrate age-related increases in overall striatal volumes specific only to COS. However, both COS and COSSIBs showed overlapping shape differences in the striatal head, which normalized in COSSIBs by late adolescence. These results mirror previous studies from our group, demonstrating cortical thickness deficits in COS and COSSIBs as these deficits normalize in COSSIBs in the same age range as our striatal findings. Finally, there is a single region of nonoverlapping outward displacement in the dorsal aspect of the caudate body, potentially indicative of a response to medication. Striatal shape may be considered complimentary to volume as an endophenotype, and, in some cases may provide information that is not detectable using standard volumetric techniques. Our striatal shape findings demonstrate the striking localization of abnormalities in striatal the head. The neuroanatomical localization of these findings suggest the presence of abnormalities in the striatal-prefrontal circuits in schizophrenia and resilience mechanisms in COSSIBs with age dependent normalization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.