Trial reportHuman brain mapping2015
Effective connectivity during episodic memory retrieval in schizophrenia participants before and after antipsychotic medication.
Trial report in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Narrative identity in the psychosis spectrum: A systematic review and developmental model.Clinical psychology review · 2021Pooled it
- The subcortical brain regions influence the cortical areas during resting-state: an fMRI study.Frontiers in human neuroscience · 2024Article
- Hippocampal Hyperconnectivity to the Visual Cortex Predicts Treatment Response.Schizophrenia bulletin · 2023Article
- Longitudinal changes in neural gain and its relationship to cognitive control trajectory in young adults with early psychosis.Translational psychiatry · 2023Article
- Brain effective connectivity and functional connectivity as markers of lifespan vascular exposures in middle-aged adults: The Bogalusa Heart Study.Frontiers in aging neuroscience · 2023Article
- Noninvasive Characterization of Functional Pathways in Layer-Specific Microcircuits of the Human Brain Using 7T fMRI.Brain sciences · 2022Article
- Stress-Induced Changes in Effective Connectivity During Regulation of the Emotional Response to Threat.Brain connectivity · 2022Article
- Hippocampal Dysconnectivity and Altered Glutamatergic Modulation of the Default Mode Network: A Combined Resting-State Connectivity and Magnetic Resonance Spectroscopy Study in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Mnemonic Discrimination Deficits in First-Episode Psychosis and a Ketamine Model Suggest Dentate Gyrus Pathology Linked to NMDA Receptor Hypofunction.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Effective Connectivity of the Hippocampus Can Differentiate Patients with Schizophrenia from Healthy Controls: A Spectral DCM Approach.Brain topography · 2021Article
- Functioning Problems in Persons with Schizophrenia in the Russian Context.International journal of environmental research and public health · 2021Article
- An Integrated Account of Expert Perspectives on Functioning in Schizophrenia.Journal of clinical medicine · 2021Article
- Functional connectivity abnormalities of the long-axis hippocampal subregions in schizophrenia during episodic memory.NPJ schizophrenia · 2021Article
- Neuroimaging as a Window Into the Pathophysiological Mechanisms of Schizophrenia.Frontiers in psychiatry · 2021Review
- Neural Signatures of Memory Encoding in Schizophrenia Are Modulated by Antipsychotic Treatment.Neuropsychobiology · 2021Article
- Disordered directional brain network interactions during learning dynamics in schizophrenia revealed by multivariate autoregressive models.Human brain mapping · 2020Article
- Long-Term Aberrations To Cerebellar Endocannabinoids Induced By Early-Life Stress.Scientific reports · 2020Article
- Deterioration from healthy to mild cognitive impairment and Alzheimer's disease mirrored in corresponding loss of centrality in directed brain networks.Brain informatics · 2019Article
- Bypassing the volume conduction effect by multilayer neural network for effective connectivity estimation.Medical & biological engineering & computing · 2019Article
- A longitudinal magnetic resonance spectroscopy study investigating effects of risperidone in the anterior cingulate cortex and hippocampus in schizophrenia.Schizophrenia research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundImpairment in episodic memory is one of the most robust findings in schizophrenia. Disruptions of fronto-temporal functional connectivity that could explain some aspects of these deficits have been reported. Recent work has identified abnormal hippocampal function in unmedicated patients with schizophrenia (SZ), such as increased metabolism and glutamate content that are not always seen in medicated SZ. For these reasons, we hypothesized that altered fronto-temporal connectivity might originate from the hippocampus and might be partially restored by antipsychotic medication.
methodsGranger causality methods were used to evaluate the effective connectivity between frontal and temporal regions in 21 unmedicated SZ and 20 matched healthy controls (HC) during performance of an episodic memory retrieval task. In 16 SZ, effective connectivity between these regions was evaluated before and after 1-week of antipsychotic treatment.
resultsIn HC, significant effective connectivity originating from the right hippocampus to frontal regions was identified. Compared to HC, unmedicated SZ showed significant altered fronto-temporal effective connectivity, including reduced right hippocampal to right medial frontal connectivity. After 1-week of antipsychotic treatment, connectivity more closely resembled the patterns observed in HC, including increased effective connectivity from the right hippocampus to frontal regions.
conclusionsThese results support the notion that memory disruption in schizophrenia might originate from hippocampal dysfunction and that medication restores some aspects of fronto-temporal dysconnectivity. Patterns of fronto-temporal connectivity could provide valuable biomarkers to identify new treatments for the symptoms of schizophrenia, including memory deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.