ArticleScience translational medicine2014
White matter changes linked to visual recovery after nerve decompression.
Article in Science translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Methods of diffusion MRI tractography for localization of the anterior optic pathway: A systematic review of validated methods.NeuroImage. Clinical · 2023Pooled it
- Choroidal microcirculation in pediatric craniopharyngioma: postoperative alterations in choroidal thickness.Frontiers in pediatrics · 2026Article
- Application of magnetic resonance diffusion tensor imaging for the treatment of hemifacial spasm.American journal of translational research · 2026Article
- Article
- Predictive visual field outcomes after optic chiasm decompressive surgery by retinal vessels parameters using optical coherence tomography angiography.International journal of ophthalmology · 2024Article
- Dynamic structural remodeling of the human visual system prompted by bilateral retinal gene therapy.Current research in neurobiology · 2023Article
- Machine Learning Prediction of Visual Outcome after Surgical Decompression of Sellar Region Tumors.Journal of personalized medicine · 2022Article
- Prolactin at moderately increased levels confers a neuroprotective effect in non-secreting pituitary macroadenomas.PloS one · 2022Article
- Modeling the Properties of White Matter Tracts Using Diffusion Tensor Imaging to Characterize Patterns of Injury in Aging and Neurodegenerative Disease.Frontiers in aging neuroscience · 2022Article
- Diffusion Tensor Imaging Profiles Can Distinguish Diffusivity and Neural Properties of White Matter Injury in Hydrocephalus vs. Non-hydrocephalus Using a Strategy of a Periodic Table of DTI Elements.Frontiers in neurology · 2022Article
- Quantitative visual pathway abnormalities predict visual field defects in patients with pituitary adenomas: a diffusion spectrum imaging study.European radiology · 2021Article
- Empty Sella Syndrome as a Window Into the Neuroprotective Effects of Prolactin.Frontiers in medicine · 2021Article
- Quantitative assessment of secondary white matter injury in the visual pathway by pituitary adenomas: a multimodal study at 7-Tesla MRI.Journal of neurosurgery · 2020Article
- Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.Nature biomedical engineering · 2019Article
- Increased resting-state functional connectivity in suprasellar tumor patients with postoperative visual improvement.International journal of medical sciences · 2019Article
- Safety and Long-Term Efficacy of AAV4 Gene Therapy in Patients with RPE65 Leber Congenital Amaurosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Individualized Map of White Matter Pathways: Connectivity-Based Paradigm for Neurosurgical Planning.Neurosurgery · 2016Article
- Impact of region-of-interest method on quantitative analysis of DTI data in the optic tracts.BMC medical imaging · 2016Article
- Plasticity of the human visual system after retinal gene therapy in patients with Leber's congenital amaurosis.Science translational medicine · 2015Article
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8 authors at 2 institutions in 1 country.
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Abstract
The relationship between the integrity of white matter tracts and cortical function in the human brain remains poorly understood. We investigate reversible white matter injury, in this case patients with compression of the optic chiasm by pituitary gland tumors, to study the structural and functional changes that attend spontaneous recovery of cortical function and visual abilities after surgical removal of the tumor and subsequent decompression of the nerves. We show that compression of the optic chiasm led to demyelination of the optic tracts, which reversed as quickly as 4 weeks after nerve decompression. Furthermore, variability across patients in the severity of demyelination in the optic tracts predicted visual ability and functional activity in early cortical visual areas. Preoperative measurements of myelination in the optic tracts predicted the magnitude of visual recovery after surgery. These data indicate that rapid regeneration of myelin in the human brain is a component of the normalization of cortical activity, and ultimately the recovery of sensory and cognitive function, after nerve decompression. More generally, our findings demonstrate the use of diffusion tensor imaging as an in vivo measure of myelination in the human brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.