ArticleThe American journal of sports medicine2015
In vivo measurement of localized tibiofemoral cartilage strains in response to dynamic activity.
Article in The American journal of sports medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Immediate and Delayed Effects of Joint Loading Activities on Knee and Hip Cartilage: A Systematic Review and Meta-analysis.Sports medicine - open · 2023Pooled it
- A New Stress Test for Knee Joint Cartilage.Scientific reports · 2019Trial
- In vivo kinematics of knee joint cartilage and meniscus contact areas under load application: a biomechanical MRI study.Archives of orthopaedic and trauma surgery · 2026Article
- A deep learning-based approach for measuring patellar cartilage deformations from knee MR images.Journal of biomechanics · 2025Article
- Respective association of joint space narrowing and osteophyte formation with knee symptoms and function in China.Journal of orthopaedic surgery and research · 2025Article
- Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage.Osteoarthritis and cartilage open · 2025Article
- Walking recovers cartilage compressive strain in vivo.Osteoarthritis and cartilage open · 2024Article
- Deep learning enables accurate soft tissue tendon deformation estimation in vivo via ultrasound imaging.Scientific reports · 2024Article
- Impact of treadmill running on distal femoral cartilage thickness: a cross-sectional study of professional athletes and healthy controls.BMC sports science, medicine & rehabilitation · 2024Article
- Visible and Near-Infrared Spectroscopy Enables Differentiation of Normal and Early Osteoarthritic Human Knee Joint Articular Cartilage.Annals of biomedical engineering · 2023Article
- Fiber reinforced hydrated networks recapitulate the poroelastic mechanics of articular cartilage.Acta biomaterialia · 2023Article
- Acute Repair of Meniscus Root Tear Partially Restores Joint Displacements as Measured With Magnetic Resonance Images and Loading in a Cadaveric Porcine Knee.Journal of biomechanical engineering · 2023Article
- Posterior subtotal meniscectomy revealed the worst scenario for the progression of osteocartilaginous damage in cases of juvenile discoid lateral meniscus with peripheral tear.Archives of orthopaedic and trauma surgery · 2023Article
- Reinforcement of Hydrogels with a 3D-Printed Polycaprolactone (PCL) Structure Enhances Cell Numbers and Cartilage ECM Production under Compression.Journal of functional biomaterials · 2023Article
- Knee kinetics and the medial femoral cartilage cross-sectional area response to loading in indviduals with anterior cruciate ligament reconstruction.Clinical biomechanics (Bristol, Avon) · 2023Article
- Applied Compressive Strain Governs Hyaline-like Cartilage versus Fibrocartilage-like ECM Produced within Hydrogel Constructs.International journal of molecular sciences · 2023Article
- Posteromedial Compartment Arthroscopy of the Knee and Resection of Osteophytes: An Anatomic Perspective on Posteromedial Knee Impingement.Arthroscopy techniques · 2022Article
- Obesity impacts the mechanical response and biochemical composition of patellofemoral cartilage: An in vivo, MRI-based investigation.Journal of biomechanics · 2022Article
- Joint distraction for osteoarthritis: clinical evidence and molecular mechanisms.Nature reviews. Rheumatology · 2022Review
- Variation characteristics of stress distribution in the subchondral bone of the knee joint of judo athletes with long-term stress changes.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAltered local mechanical loading may disrupt normal cartilage homeostasis and play a role in the progression of osteoarthritis. Currently, there are limited data quantifying local cartilage strains in response to dynamic activity in normal or injured knees. PURPOSE/HYPOTHESIS: To directly measure local tibiofemoral cartilage strains in response to a dynamic hopping activity in normal healthy knees. We hypothesized that local regions of cartilage will exhibit significant compressive strains in response to hopping, while overall compartmental averages may not. STUDY
designControlled laboratory study.
methodsBoth knees of 8 healthy subjects underwent magnetic resonance imaging before and immediately after a dynamic hopping activity. Images were segmented and then used to create 3-dimensional surface models of bone and cartilage. These pre- and postactivity models were then registered using an iterative closest point technique to enable site-specific measurements of cartilage strain (defined as the normalized change in cartilage thickness before and after activity) on the femur and tibia.
resultsSignificant strains were observed in both the medial and lateral tibial cartilage, with each compartment averaging a decrease of 5%. However, these strains varied with location within each compartment, reaching a maximum compressive strain of 8% on the medial plateau and 7% on the lateral plateau. No significant averaged compartmental strains were observed in the medial or lateral femoral cartilage. However, local regions of the medial and lateral femoral cartilage experienced significant compressive strains, reaching maximums of 6% and 3%, respectively.
conclusionLocal regions of both the femur and tibia experienced significant cartilage strains as a result of dynamic activity. An understanding of changes in cartilage strain distributions may help to elucidate the biomechanical factors contributing to cartilage degeneration after joint injury. CLINICAL RELEVANCE: Site-specific measurements of in vivo cartilage strains are important because altered loading is believed to be a factor contributing to the development and progression of osteoarthritis. Specifically, this methodology and data could be used to evaluate the effects of soft tissue injuries (such as ligament or meniscus tears) on cartilage strains in response to dynamic activities of daily living.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.