Evidence map›Paper›PMID 25504759›Full record

ArticleCirculation. Heart failure2015

Enhanced skeletal muscle expression of extracellular superoxide dismutase mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling.

Jarrod A Call, Kristopher H Chain, Kyle S Martin, Vitor A Lira, Mitsuharu Okutsu, Mei Zhang, Zhen Yan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
13.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  5. Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
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  6. Article
  7. Review
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  9. Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  10. Effects of Heme Oxygenase-1 on c-Kit-Positive Cardiac Cells.International journal of molecular sciences · 2021
    Article
  11. A novel voluntary weightlifting model in mice promotes muscle adaptation and insulin sensitivity with simultaneous enhancement of autophagy and mTOR pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
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  12. Review
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  18. Tumor necrosis factor-α decreases EC-SOD expression through DNA methylation.Journal of clinical biochemistry and nutrition · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jarrod A CallFrom the Departments of Medicine (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), Pharmacology (Z.Y.), Molecular Physiology and Biological Physics (Z.Y.), Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), and Department of Biomedical Engineering (K.S.M.), University of Virginia, Charlottesville.
Kristopher H ChainFrom the Departments of Medicine (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), Pharmacology (Z.Y.), Molecular Physiology and Biological Physics (Z.Y.), Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), and Department of Biomedical Engineering (K.S.M.), University of Virginia, Charlottesville.
Kyle S MartinFrom the Departments of Medicine (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), Pharmacology (Z.Y.), Molecular Physiology and Biological Physics (Z.Y.), Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), and Department of Biomedical Engineering (K.S.M.), University of Virginia, Charlottesville.
Vitor A LiraFrom the Departments of Medicine (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), Pharmacology (Z.Y.), Molecular Physiology and Biological Physics (Z.Y.), Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), and Department of Biomedical Engineering (K.S.M.), University of Virginia, Charlottesville.
Mitsuharu OkutsuFrom the Departments of Medicine (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), Pharmacology (Z.Y.), Molecular Physiology and Biological Physics (Z.Y.), Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), and Department of Biomedical Engineering (K.S.M.), University of Virginia, Charlottesville.
Mei ZhangFrom the Departments of Medicine (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), Pharmacology (Z.Y.), Molecular Physiology and Biological Physics (Z.Y.), Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), and Department of Biomedical Engineering (K.S.M.), University of Virginia, Charlottesville.
Zhen YanFrom the Departments of Medicine (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), Pharmacology (Z.Y.), Molecular Physiology and Biological Physics (Z.Y.), Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center (J.A.C., K.H.C., V.A.L., M.O., M.Z., Z.Y.), and Department of Biomedical Engineering (K.S.M.), University of Virginia, Charlottesville. zhen.yan@virginia.edu.
Cardiovascular Research Center · BR

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
p38 MAPK a regulator of muscle contraction and functionR01AR050429 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YAN, ZHEN · 2005 to 2022
$5.3M
NO-dependent SOD3 protection against cachexiaR21AR060444 · NIAMS · UNIVERSITY OF VIRGINIA · PI YAN, ZHEN · 2011 to 2012
$381k
NHLBI NIH HHS T32 HL007284NHLBI NIH HHS T32-HL007284NIAMS NIH HHS AR050429NIAMS NIH HHS R01 AR050429NIAMS NIH HHS R21 AR060444
6 · The paper itself

Abstract

backgroundExercise training enhances extracellular superoxide dismutase (EcSOD) expression in skeletal muscle and elicits positive health outcomes in individuals with diabetes mellitus. The goal of this study was to determine if enhanced skeletal muscle expression of EcSOD is sufficient to mitigate streptozotocin-induced diabetic cardiomyopathy. METHODS AND

resultsExercise training promotes EcSOD expression in skeletal muscle and provides protection against diabetic cardiomyopathy; however, it is not known if enhanced expression of EcSOD in skeletal muscle plays a functional role in this protection. Here, we show that skeletal muscle-specific EcSOD transgenic mice are protected from cardiac hypertrophy, fibrosis, and dysfunction under the condition of type 1 diabetes mellitus induced by streptozotocin injection. We also show that both exercise training and muscle-specific transgenic expression of EcSOD result in elevated EcSOD protein in the blood and heart without increased transcription in the heart, suggesting that enhanced expression of EcSOD from skeletal muscle redistributes to the heart. Importantly, cardiac tissue in transgenic mice displayed significantly reduced oxidative stress, aberrant cell signaling, and inflammatory cytokine expression compared with wild-type mice under the same diabetic condition.

conclusionsEnhanced expression of EcSOD in skeletal muscle is sufficient to mitigate streptozotocin-induced diabetic cardiomyopathy through attenuation of oxidative stress, aberrant cell signaling, and inflammation, suggesting a cross-organ mechanism by which exercise training improves cardiac function in diabetes mellitus.

Indexed as

Gene Expression RegulationOxidative StressAnimalsBlotting, WesternDiabetes Mellitus, ExperimentalDiabetic CardiomyopathiesDNAMaleMiceMice, Inbred C57BLMice, TransgenicMuscle, SkeletalMyocytes, CardiacReverse Transcriptase Polymerase Chain ReactionSignal TransductionSuperoxide DismutaseDNASuperoxide Dismutaseantioxidantscardiomyocytediabetic cardiomyopathiesexercisehypertrophyoxidative stress

Identifiers

PMID25504759
PMCPMC4445759
OpenAlexW2082278578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.