ArticleMagnetic resonance in chemistry : MRC2015
Electron spin relaxation times and rapid scan EPR imaging of pH-sensitive amino-substituted trityl radicals.
Article in Magnetic resonance in chemistry : MRC, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Rapid Scan EPR imaging as a Tool for Magnetic Field Mapping.Applied magnetic resonance · 2020Article
- General solution for rapid scan EPR deconvolution problem.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Chemical exchange induced Hahn echo modulation in pulsed electron paramagnetic resonance experiment.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Development of a fast-scan EPR imaging system for highly accelerated free radical imaging.Magnetic resonance in medicine · 2019Article
- Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K.Journal of visualized experiments : JoVE · 2019Article
- A combined positron emission tomography (PET)-electron paramagnetic resonance imaging (EPRI) system: initial evaluation of a prototype scanner.Physics in medicine and biology · 2018Article
- Full cycle rapid scan EPR deconvolution algorithm.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo.Journal of visualized experiments : JoVE · 2016Article
- Rapid-Scan EPR of Nitroxide Spin Labels and Semiquinones.Methods in enzymology · 2015Article
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7 authors.
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Abstract
Carboxy-substituted trityl (triarylmethyl) radicals are valuable in vivo probes because of their stability, narrow lines, and sensitivity of their spectroscopic properties to oxygen. Amino-substituted trityl radicals have the potential to monitor pH in vivo, and the suitability for this application depends on spectral properties. Electron spin relaxation times T1 and T2 were measured at X-band for the protonated and deprotonated forms of two amino-substituted triarylmethyl radicals. Comparison with relaxation times for carboxy-substituted triarylmethyl radicals shows that T1 exhibits little dependence on protonation or the nature of the substituent, which makes it useful for measuring O2 concentration, independent of pH. Insensitivity of T1 to changes in substituents is consistent with the assignment of the dominant contribution to spin lattice relaxation as a local mode that involves primarily atoms in the carbon and sulfur core. Values of T2 vary substantially with pH and the nature of the aryl group substituent, reflecting a range of dynamic processes. The narrow spectral widths for the amino-substituted triarylmethyl radicals facilitate spectral-spatial rapid scan electron paramagnetic resonance imaging, which was demonstrated with a phantom. The dependence of hyperfine splittings patterns on pH is revealed in spectral slices through the image.
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