ArticleNature structural & molecular biology2015
Human cells contain natural double-stranded RNAs with potential regulatory functions.
Article in Nature structural & molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Pervasive formation of double-stranded RNAs by overlapping sense/antisense transcripts in budding yeast mitosis and meiosis.RNA (New York, N.Y.) · 2025Article
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- Advances in A-to-I RNA editing in cancer.Molecular cancer · 2024Review
- Natural antisense transcripts as versatile regulators of gene expression.Nature reviews. Genetics · 2024Review
- Removal of Double-Stranded RNA Contaminants During Template-Directed Synthesis of mRNA.Bulletin of experimental biology and medicine · 2024Article
- A Dual Role of DDX3X in dsRNA-Derived Innate Immune Signaling.Frontiers in molecular biosciences · 2022Review
- Alu RNA Structural Features Modulate Immune Cell Activation and A-to-I Editing of Alu RNAs Is Diminished in Human Inflammatory Bowel Disease.Frontiers in immunology · 2022Article
- Reduced RNA adenosine-to-inosine editing in hippocampus vasculature associated with Alzheimer's disease.Brain communications · 2022Article
- Computational analysis of sense-antisense chimeric transcripts reveals their potential regulatory features and the landscape of expression in human cells.NAR genomics and bioinformatics · 2021Article
- Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.Cancer research · 2021Article
- Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Reduced A-to-I editing of endogenous Alu RNAs in lung after SARS-CoV-2 infection.Current research in immunology · 2021Article
- Adenosine-to-Inosine RNA Editing of Alu Double-Stranded (ds)RNAs Is Markedly Decreased in Multiple Sclerosis and Unedited Alu dsRNAs Are Potent Activators of Proinflammatory Transcriptional Responses.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- The internal loops in the lower stem of primary microRNA transcripts facilitate single cleavage of human Microprocessor.Nucleic acids research · 2020Article
- Activation of Toll-Like Receptor 3 Induces Interleukin-1 Receptor Antagonist Expression by Activating the Interferon Regulatory Factor 3.Journal of innate immunity · 2020Article
- Endogenous double-stranded Alu RNA elements stimulate IFN-responses in relapsing remitting multiple sclerosis.Journal of autoimmunity · 2019Article
- The anti-cancer drug 5-fluorouracil affects cell cycle regulators and potential regulatory long non-coding RNAs in yeast.RNA biology · 2019Article
- A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA.Molecular therapy. Nucleic acids · 2019Article
- Noncoding RNA Ginir functions as an oncogene by associating with centrosomal proteins.PLoS biology · 2018Article
- A regulatory RNA is involved in RNA duplex formation and biofilm regulation in Sulfolobus acidocaldarius.Nucleic acids research · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence has suggested the existence of sense-antisense transcription in mammals, but the existence of double-stranded RNAs endowed with biological function has remained elusive. Herein we show that hundreds of putative natural double-stranded RNAs (ndsRNAs) are expressed from interspersed genomic locations and respond to cellular cues. We demonstrate that a subset of ndsRNAs localize in the nucleus and, in their double-stranded form, interact with nuclear proteins. Detailed characterization of an ndsRNA (nds-2a) revealed that this molecule displays differential localization throughout the cell cycle and directly interacts with RCC1 and RAN and, through the latter, with the mitotic RANGAP1-SUMO1-RANBP2 complex. Notably, altering nds-2a levels led to postmitotic abnormalities, mitotic catastrophe and cell death, thus supporting a mitosis-related role. Altogether, our study reveals a hitherto-unrecognized class of RNAs that potentially participate in major biological processes in human cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.