ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2014
Genomic study of ossification of the posterior longitudinal ligament of the spine.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- The relationship between OPLL and metabolic disorders.Bone research · 2025Review
- Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament.Frontiers of medicine · 2024Article
- Direct anterior decompression in patients with ossification of the posterior longitudinal ligament significantly relieves short-segment spinal cord high signal.BMC musculoskeletal disorders · 2024Article
- Differences in the Demographics and Clinical Characteristics between the Ossification of the Posterior Longitudinal Ligament and Ossification of the Ligamentum Flavum in Patients Who Underwent Thoracic Spinal Surgery for Compressive Myelopathy.Neurologia medico-chirurgica · 2024Article
- Integrin αVβ3 antagonist-c(RGDyk) peptide attenuates the progression of ossification of the posterior longitudinal ligament by inhibiting osteogenesis and angiogenesis.Molecular medicine (Cambridge, Mass.) · 2024Article
- Hao1 Is Not a Pathogenic Factor for Ectopic Ossifications but Functions to Regulate the TCA Cycle In Vivo.Metabolites · 2022Article
- The Effect of the NFOxidative medicine and cellular longevity · 2022Article
- Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire as an outcome measure for ossification of posterior longitudinal ligament patients in East Asia: an investigation of reliability, validity, and responsiveness.Annals of translational medicine · 2021Article
- MicroRNA-181 regulates the development of Ossification of Posterior longitudinal ligament via Epigenetic Modulation by targeting PBX1.Theranostics · 2020Article
- The COL6A1 rs201153092 single nucleotide polymorphism, associates with thoracic ossification of the posterior longitudinal ligament.Molecular medicine reports · 2020Article
- A new single nucleotide polymorphism affects the predisposition to thoracic ossification of the posterior longitudinal ligament.Journal of orthopaedic surgery and research · 2019Article
- Ossification of Posterior Longitudinal Ligament of Cervical Spine Among Omani Patients Referred for CT Scan at a Tertiary Care Hospital in Oman.Oman medical journal · 2019Article
- Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament.Global spine journal · 2019Article
- IL17RC affects the predisposition to thoracic ossification of the posterior longitudinal ligament.Journal of orthopaedic surgery and research · 2019Article
- Review
- Molecular Pathophysiology of Ossification of the Posterior Longitudinal Ligament (OPLL).Biomolecules & therapeutics · 2019Review
- Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament.International journal of molecular medicine · 2019Article
- Association of IL17RC and COL6A1 genetic polymorphisms with susceptibility to ossification of the thoracic posterior longitudinal ligament in Chinese patients.Journal of orthopaedic surgery and research · 2018Article
- Genetic polymorphisms in bone morphogenetic protein receptor type IA gene predisposes individuals to ossification of the posterior longitudinal ligament of the cervical spine via the smad signaling pathway.BMC musculoskeletal disorders · 2018Article
- The Pathogenesis of Ossification of the Posterior Longitudinal Ligament.Aging and disease · 2017Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common disease after the middle age. OPLL frequently causes serious neurological problems due to compression of the spinal cord and/or nerve roots. OPLL occurs in patients with monogenic metabolic diseases including rickets/osteomalacia and hypoparathyroidism; however most of OPLL is idiopathic and is considered as a multi-factorial (polygenic) disease influenced by genetic and environmental factors. Genomic studies for the genetic factors of OPLL have been conducted, mainly in Japan, including linkage and association studies. This paper reviews the recent progress in the genomic study of OPLL and comments on its future direction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.