ArticleEuropean journal of pediatrics2015
Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis: a case-control study from a tertiary care center in Turkey.
Article in European journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03087149 (Supplementation of Vitamin D in Preterm Infants- Monitored Therapy vs Standard Therapy. A Randomized Controlled Trial), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Supplementation of Vitamin D in Preterm Infants- Monitored Therapy vs Standard Therapy. A Randomized Controlled Trial
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Vitamin D status was associated with sepsis in critically ill children: A PRISMA compliant systematic review and meta-analysis.Medicine · 2021Pooled it
- Pooled it
- Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review.Nutrition reviews · 2016Pooled it
- Vitamin D and Neonatal Sepsis: Current Evidence, Biological Mechanisms, and Future Directions-A Scoping Review.Nutrients · 2026Article
- The Role of Vitamin D and Vitamin D Receptor in Sepsis.Current issues in molecular biology · 2025Review
- Determining the Relationship Between Maternal and Neonatal Vitamin D Serum Levels in Term Infants With and Without Sepsis.Journal of family & reproductive health · 2025Article
- Association of low vitamin D level and full-term early-onset neonatal sepsis; a case-control study.Italian journal of pediatrics · 2024Article
- Is 25OH Vitamin D Excess before 36 Weeks Corrected Age an Independent Risk Factor for Bronchopulmonary Dysplasia or Death?Nutrients · 2023Article
- Vitamin D Deficiency: An Underestimated Factor in Sepsis?International journal of molecular sciences · 2023Review
- Clinical Risk Factors for Early-Onset Sepsis in Neonates: An International Delphi Study.Iranian journal of medical sciences · 2023Review
- Effects of vitamin D on neonatal sepsis: A systematic review and meta-analysis.Food science & nutrition · 2021Article
- Is Lower Vitamin D Level Associated with Increased Risk of Neonatal Sepsis? A Prospective Cohort Study.Indian journal of pediatrics · 2020Article
- Vitamin D deficiency and its effect on respiratory distress syndrome in premature infants: results from a prospective study in a tertiary care centre.African health sciences · 2020Article
- Effects of vitamin D on apoptosis of T-lymphocyte subsets in neonatal sepsis.Experimental and therapeutic medicine · 2018Article
- [Predictive value of cord blood 25(OH)D3 for early infantile atopic dermatitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- [Relationship between serum 25(OH)D levels at birth and respiratory distress syndrome in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants.Korean journal of pediatrics · 2017Article
- Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study.Scientific reports · 2017Article
- Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications.Therapeutic advances in musculoskeletal disease · 2016Review
- Observational
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledVitamin D has been linked with immunity, and the immunomodulatory role of this molecule in regulating key elements of the immune system has become an area of intense scientific investigation. We designed a case-control study to investigate whether neonates with early-onset neonatal sepsis (EONS) had lower levels of vitamin D. The primary exposure for the analysis in the study was the cord-blood level of 25-hydroxyvitamin D (25(OH)D). Of the 2571 live births occurring during the 18-month study period, 53 infants were admitted to the neonatal intensive care unit with suspected EONS. After clinical and laboratory confirmation, 40 newborns with EONS and 43 controls were analyzed. Cord-blood 25(OH)D levels of infants in the study group were significantly lower than that of the control group (median 12.6 ng/mL (3.1-78.9) vs. 21 (5-118); p = 0.038, respectively). In multivariate models, a low cord-blood 25(OH)D level (<30 ng/ml) was associated with an increased risk of EONS (OR = 5.6; 95% CI = 1.3-23.5).
conclusionCord-blood 25(OH)D levels of neonates with EONS were significantly lower than that of the healthy controls, and a low level of cord-blood vitamin D was found to be associated with an increased risk of EONS. Further studies are warranted to confirm this association.
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