ArticlePLoS computational biology2014
Two-dimensionality of yeast colony expansion accompanied by pattern formation.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The role ofmBio · 2026Article
- Transition from traveling fronts to diffusion-limited growth in expanding populations.Physical review. E · 2026Article
- Article
- Mechanistic regulation of planarian shape during growth and degrowth.Development (Cambridge, England) · 2024Article
- Integrative analysis of yeast colony growth.Communications biology · 2024Article
- Intra-colony channel morphology inBiofilm · 2022Article
- Growth instabilities shape morphology and genetic diversity of microbial colonies.Physical biology · 2022Article
- Spatial regulation of cell motility and its fitness effect in a surface-attached bacterial community.The ISME journal · 2022Article
- Drug-dependent growth curve reshaping reveals mechanisms of antifungal resistance in Saccharomyces cerevisiae.Communications biology · 2022Article
- Repulsive expansion dynamics in colony growth and gene expression.PLoS computational biology · 2021Article
- Characterization ofJournal of fungi (Basel, Switzerland) · 2021Article
- Lattice-based Monte Carlo simulation of the effects of nutrient concentration and magnetic field exposure on yeast colony growth and morphology.In silico biology · 2021Article
- Article
- A thin-film extensional flow model for biofilm expansion by sliding motility.Proceedings. Mathematical, physical, and engineering sciences · 2019Article
- Disadvantages and benefits of evolved unicellularity versus multicellularity in budding yeast.Ecology and evolution · 2019Article
- Multiscale effects of heating and cooling on genes and gene networks.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Characterizing the shape patterns of dimorphic yeast pseudohyphae.Royal Society open science · 2018Article
- Biofilm formation and toxin production provide a fitness advantage in mixed colonies of environmental yeast isolates.Ecology and evolution · 2018Article
- Diffusion-Limited Growth of Microbial Colonies.Scientific reports · 2018Article
- Programmable assembly of pressure sensors using pattern-forming bacteria.Nature biotechnology · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Yeasts can form multicellular patterns as they expand on agar plates, a phenotype that requires a functional copy of the FLO11 gene. Although the biochemical and molecular requirements for such patterns have been examined, the mechanisms underlying their formation are not entirely clear. Here we develop quantitative methods to accurately characterize the size, shape, and surface patterns of yeast colonies for various combinations of agar and sugar concentrations. We combine these measurements with mathematical and physical models and find that FLO11 gene constrains cells to grow near the agar surface, causing the formation of larger and more irregular colonies that undergo hierarchical wrinkling. Head-to-head competition assays on agar plates indicate that two-dimensional constraint on the expansion of FLO11 wild type (FLO11) cells confers a fitness advantage over FLO11 knockout (flo11Δ) cells on the agar surface.
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Registered trials
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