Evidence map›Paper›PMID 25504030›Full record

Trial reportDiabetes care2015

PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial.

Tao Huang, Jinyan Huang, Qibin Qi, Yanping Li, George A Bray, Jennifer Rood, Frank M Sacks, Lu Qi

Open access · bronzeAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  7. Review
  8. Article
  9. PCSK7 levels in women with and without PCOS.Journal of clinical & translational endocrinology · 2024
    Article
  10. Review
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  13. Article
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  18. Article
  19. Article
  20. Nutrition and Genetics in NAFLD: The Perfect Binomium.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Tao HuangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Jinyan HuangDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.
Qibin QiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Yanping LiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
George A BrayPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA.
Jennifer RoodPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA.
Frank M SacksDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Lu QiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA nhlqi@channing.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USLouisiana State University · USPennington Biomedical Research Center · US

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0M
Genetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9M
Obesity Genes, Energy Regulation in Response to Weight-Loss DietsR01DK091718 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2012 to 2021
$4.5M
NHLBI NIH HHS HL-071981NHLBI NIH HHS R01 HL071981NIDDK NIH HHS DK-091718NIDDK NIH HHS DK-46200NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK091718
6 · The paper itself

Abstract

objectiveA common variant rs236918 in the PCSK7 gene has the strongest association with iron homeostasis and is related to insulin resistance. Dietary carbohydrate (CHO) modulates the genetic effect on insulin resistance. We examined whether 2-year weight-loss diets modify the effect of PCSK7 genetic variants on changes in fasting insulin levels and insulin resistance in a randomized, controlled trial. RESEARCH DESIGN AND

methodsData were analyzed in the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial, which is a randomized, controlled 2-year weight-loss trial using diets that differed in macronutrient proportions. PCSK7 rs236918 was genotyped in 730 overweight or obese adults (80% whites) in this trial. We assessed the progression in fasting insulin and glucose levels, and insulin resistance by genotypes.

resultsDuring the 6-month weight-loss phase, the PCSK7 rs236918 G allele was significantly associated with greater decreases in fasting insulin levels in the high-dietary CHO group (P for interaction = 0.04), while the interaction for changes in HOMA-insulin resistance (HOMA-IR) (P for interaction = 0.06) did not reach significant levels in white subjects. The G allele was significantly associated with a greater decrease in fasting insulin levels and HOMA-IR in response to high dietary CHO levels (P = 0.02 and P = 0.03, respectively). From 6 months to 2 years (weight-regain phase), the interactions became attenuated due to the regaining of weight (P for interactions = 0.08 and 0.06, respectively). In addition, we observed similar and even stronger results in the whole-study samples from the trial.

conclusionsOur data suggest that PCSK7 genotypes may interact with dietary CHO intake on changes in insulin sensitivity in the white Americans.

Indexed as

AllelesBody WeightDietary CarbohydratesDiet, ReducingFastingFemaleGenotypeHomeostasisHumansInsulinInsulin ResistanceIronMaleMiddle AgedOverweightSubtilisinsDietary CarbohydratesInsulinIronPCSK7 protein, humanSubtilisins

Identifiers

PMID25504030
PMCPMC4876697
OpenAlexW2112846635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.