Evidence map›Paper›PMID 25503981›Full record

ArticleNeurology2015

Alcohol consumption, drinking patterns, and cognitive function in older Eastern European adults.

Pia Horvat, Marcus Richards, Ruzena Kubinova, Andrzej Pajak, Sofia Malyutina, Sergey Shishkin, Hynek Pikhart, Anne Peasey, M G Marmot, Archana Singh-Manoux and 1 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  10. Iso-α-acids, the bitter components of beer, improve hippocampus-dependent memory through vagus nerve activation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Pia HorvatFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France. pia.horvat.10@ucl.ac.uk.
Marcus RichardsFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France.
Ruzena KubinovaFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France.
Andrzej PajakFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France.
Sofia MalyutinaFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France.
Sergey ShishkinFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France.
Hynek PikhartFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France.
Anne PeaseyFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France.
M G MarmotFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France.
Archana Singh-ManouxFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France.
Martin BobakFrom the Department of Epidemiology & Public Health (P.H., H.P., A. Peasey, M.G.M., A.S.-M., M.B.), and MRC Unit for Lifelong Health and Ageing at UCL (M.R.), University College London, UK; National Institute of Public Health (R.K.), Prague, Czech Republic; Department of Epidemiology and Population Studies (A. Pajak), Jagellonian University Collegium Medicum, Krakow, Poland; Institute of Internal and Preventive Medicine Siberian Branch under the Russian Academy of Medical Sciences (S.M., S.S.), Novosibirsk; Novosibirsk State Medical University (S.M.), Novosibirsk, Russia; and INSERM (A.S.-M.), U1018, Hopital Paul Brousse, Villejuif, France.
Research Institute of Therapy and Preventive Medicine · RUNational Institute of Public Health · CZ

Funding

Health disparities and agingin societies in transitionR01AG023522 · NIA · UNIVERSITY COLLEGE LONDON · PI MARMOT, MICHAEL G · 2004 to 2008
$2.2M
British Heart Foundation RG/07/008/23674Medical Research Council G0100222Medical Research Council G0601647Medical Research Council G0701830Medical Research Council G0902037Medical Research Council G1000616Medical Research Council G19/35Medical Research Council G8802774Medical Research Council MR/K013351/1NIA NIH HHS R01 AG23522Wellcome Trust 064947Wellcome Trust 081081
6 · The paper itself

Abstract

objectiveTo investigate associations of frequency, quantity, binge, and problem drinking with cognitive function in older Eastern European adults.

methodsThe investigation included 14,575 participants, aged 47 to 78 years at cognitive assessment in 2006-2008 from Novosibirsk (Russia), Krakow (Poland), and 6 Czech towns participating in the HAPIEE (Health, Alcohol, and Psychosocial Factors in Eastern Europe) prospective cohort study. Average response rates were 59% at baseline (2002-2005) and 63% in 2006-2008. Alcohol consumption was assessed at baseline and in 2006-2008. Cognitive tests included immediate and delayed word recall, semantic fluency (animal naming), and letter cancellation. Associations between alcohol indices and cognitive scores were analyzed cross-sectionally (all measures from 2006 to 2008) and prospectively (alcohol and covariates from 2002 to 2005 and cognition from 2006 to 2008).

resultsIn cross-sectional analyses, nondrinkers had lower cognitive scores and female moderate drinkers had better cognitive performance than light drinkers. Heavy, binge, and problem drinking were not consistently associated with cognitive function. Few associations were replicated in prospective analyses. Participants who stopped drinking during follow-up had worse cognition than stable drinkers; in men, regression coefficients (95% confidence interval) ranged from -0.26 (-0.36, -0.16) for immediate recall to -0.14 (-0.24, -0.04) for fluency.

conclusionRegular and episodic heavy drinking were not consistently associated with cognitive function. Worse cognition in participants who stopped drinking during follow-up suggests that inclusion of less healthy ex-drinkers may partly explain poorer cognition in nondrinkers.

Indexed as

Drinking BehaviorAgedAlcohol DrinkingCognition DisordersCohort StudiesCross-Sectional StudiesEurope, EasternFemaleHumansMaleMiddle AgedNeuropsychological TestsRegression AnalysisSex Factors

Identifiers

PMID25503981
PMCPMC4335999
OpenAlexW2152349458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.