ReviewHypertension research : official journal of the Japanese Society of Hypertension2015
Systolic hypertension: an increasing clinical challenge in Asia.
Review in Hypertension research : official journal of the Japanese Society of Hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04841902 (Effects of Life Style Intervention Manual on Metabolic, Cardiovascular, Respiratory and Physical Parameters in Pre Hypertensive Sedentary Population), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Life Style Intervention Manual on Metabolic, Cardiovascular, Respiratory and Physical Parameters in Pre Hypertensive Sedentary Population
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- The effect of auricular therapy on blood pressure: A systematic review and meta-analysis.European journal of cardiovascular nursing · 2020Pooled it
- Development of an Intervention to Promote Physical Activity and Reduce Dietary Sodium Intake for Preventing Hypertension and Chronic Disease in Filipino Americans.Journal of racial and ethnic health disparities · 2021Trial
- Trial
- Efficacy and safety of sacubitril/valsartan compared with olmesartan in Asian patients with essential hypertension: A randomized, double-blind, 8-week study.Journal of clinical hypertension (Greenwich, Conn.) · 2019Trial
- Blood pressure lowering efficacy of sacubitril/allisartan versus olmesartan in elderly Chinese hypertensive patients.Journal of geriatric cardiology : JGC · 2026Article
- Simulating a Specialist's Treatment Experience for Hypertension Using Deep Neural Networks.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- A cross-sectional study of the relationship between health literacy and health-promoting lifestyles in patients with hypertension in northwest Iran.BMC primary care · 2025Article
- Global variation in antibiotic prescribing guidelines and the implications for decreasing AMR in the future.Frontiers in pharmacology · 2025Review
- Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk.European heart journal. Imaging methods and practice · 2025Article
- The relationships among disease perception, perceived control, and self-care behaviors in hypertensive patients: Results of a cross-sectional study.Journal of education and health promotion · 2025Article
- The prevalence and risk factors associated with hypertension subtypes among ethnic Dai adults in rural China.Preventive medicine reports · 2024Article
- Sacubitril/Valsartan in Heart Failure with Hypertension Patients: Real-World Experiences on Different Ages, Drug Doses, and Renal Functions.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023Article
- Network meta-analysis of sacubitril/valsartan for the treatment of essential hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Review
- Associations between long-term blood pressure trajectory and all-cause and CVD mortality among old people in China.Frontiers in cardiovascular medicine · 2023Article
- Comparison of Perceived Self-efficacy, Benefits, and Barriers of Hypertension Control between Male and Female Patients Referred to Rajaie Cardiovascular Medical and Research Center in Tehran.The journal of Tehran Heart Center · 2023Article
- RSSDI Guidelines for the management of hypertension in patients with diabetes mellitus.International journal of diabetes in developing countries · 2022Review
- A geodatabase of blood pressure level and the associated factors including lifestyle, nutritional, air pollution, and urban greenspace.BMC research notes · 2021Article
- The Antihypertensive Effects and Safety of LCZ696 in Patients with Hypertension: A Systemic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2021Review
- Thoracic Aortic Calcification and Pre-Clinical Hypertension by New 2017 ACC/AHA Hypertension Guidelines.Diagnostics (Basel, Switzerland) · 2021Article
- Blood pressure and adiposity in midlife Singaporean women.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systolic hypertension, the predominant form of hypertension in patients aged over 50-60 years, is a growing health issue as the Asian population ages. Elevated systolic blood pressure is mainly caused by arterial stiffening, resulting from age-related vascular changes. Elevated systolic pressure increases the risk of cardiovascular disease, mortality and renal function decline, and this risk may increase at lower systolic pressure levels in Asian than Western subjects. Hence, effective systolic pressure lowering is particularly important in Asians yet blood pressure control remains inadequate despite the availability of numerous antihypertensive medications. Reasons for poor blood pressure control include low awareness of hypertension among health-care professionals and patients, under-treatment, and tolerability problems with antihypertensive drugs. Current antihypertensive treatments also lack effects on the underlying vascular pathology of systolic hypertension, so novel drugs that address the pathophysiology of arterial stiffening are needed for optimal management of systolic hypertension and its cardiovascular complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.