ArticleBreast cancer research and treatment2015
Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based screening program.
Article in Breast cancer research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Subsequent breast cancer risk after benign breast biopsy in racially diverse women: Siteman Cancer Center.Journal of the National Cancer Institute · 2026Article
- Serum Uric Acid Levels and the Risk of Breast Cancer and Benign Breast Tumors: A Systematic Review and Meta-Analysis.Health science reports · 2026Article
- Comparative spectral analysis of blood and saliva in breast cancer, benign breast disease and healthy controls using ATR-FTIR.Scientific reports · 2026Article
- Spatially Resolved Single-Cell Morphometry of Benign Breast Disease Biopsy Images Uncovers Quantitative Cytomorphometric Features Predictive of Subsequent Invasive Breast Cancer Risk.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025Article
- A systematic review of determinants of breast cancer risk among women with benign breast disease.NPJ breast cancer · 2025Article
- Understanding Benign Breast Disease and Subsequent Breast Cancer in Hispanic White Females: A Step Closer to Evidence-Based Management.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England.BMJ (Clinical research ed.) · 2024Observational
- Benign Breast Disease and Breast Cancer Risk in the Percutaneous Biopsy Era.JAMA surgery · 2024Article
- Association between breast diseases and symptomatic uterine fibroids by using South Korean National Health Insurance database.Scientific reports · 2023Article
- Personalized Breast Cancer Screening: A Risk Prediction Model Based on Women Attending BreastScreen Norway.Cancers · 2023Article
- Multi-MicroRNA Analysis Can Improve the Diagnostic Performance of Mammography in Determining Breast Cancer Risk.The breast journal · 2023Article
- Microcalcifications, mammographic breast density, and risk of breast cancer: a cohort study.Breast cancer research : BCR · 2022Article
- Breast Cancer in Asia: Incidence, Mortality, Early Detection, Mammography Programs, and Risk-Based Screening Initiatives.Cancers · 2022Review
- Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography.International journal of environmental research and public health · 2022Article
- Article
- Mammographic features of benign breast lesions and risk of subsequent breast cancer in women attending breast cancer screening.European radiology · 2022Article
- Breast density, benign breast disease, and risk of breast cancer over time.European radiology · 2021Article
- Developing and validating an individualized breast cancer risk prediction model for women attending breast cancer screening.PloS one · 2021Article
- Differences in breast cancer risk after benign breast disease by type of screening diagnosis.Breast (Edinburgh, Scotland) · 2020Article
- A survey of Canadian breast health professionals’ recommendations for high-risk benign breast diseaseCanadian journal of surgery. Journal canadien de chirurgie · 2019Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influence of a family history of breast cancer. A retrospective cohort study was conducted in 545,171 women aged 50-69 years biennially screened for breast cancer in Spain. The median of follow-up was 6.1 years. The age-adjusted rate ratio (RR) of breast cancer for women with benign breast disease, histologically classified into nonproliferative and proliferative disease with and without atypia, compared with women without benign breast disease was estimated by Poisson regression analysis. A stratified analysis by family history of breast cancer was performed in a subsample. All tests were two-sided. The age-adjusted RR of breast cancer after diagnosis of benign breast disease was 2.51 (95 % CI: 2.14-2.93) compared with women without benign breast disease. The risk was higher in women with proliferative disease with atypia (RR = 4.56, 95 % CI: 2.06-10.07) followed by those with proliferative disease without atypia (RR = 3.58; 95 % CI = 2.61-4.91). Women with nonproliferative disease and without a family history of breast cancer remained also at increased risk of cancer (OR = 2.23, 95 % CI: 1.86-2.68). An increased risk of breast cancer was observed among screening participants with proliferative or nonproliferative benign breast disease, regardless of a family history of breast cancer. This information may be useful to explore risk-based screening strategies.
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