ArticleAmerican journal of physiology. Renal physiology2015
Chronic ANG II infusion induces sex-specific increases in renal T cells in Sprague-Dawley rats.
Article in American journal of physiology. Renal physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
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- Sex differences in the renal T cell profile in DOCA-salt hypertension are independent of MR activation and increases in blood pressure.American journal of physiology. Renal physiology · 2026Article
- Novel Advances in Our Understanding of Sex-Dependent Control of Blood Pressure.Annual review of physiology · 2026Review
- Paradoxical sex differences in a hamster model of angiotensin II-dependent hypertension and associated renal injury.Biology of sex differences · 2025Article
- HMGB1 drives T-cell activation in hypertensive males and females.American journal of physiology. Renal physiology · 2025Article
- Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting.Pharmacological reviews · 2022Review
- Hypertension and human immunodeficiency virus: A paradigm for epithelial sodium channels?Frontiers in cardiovascular medicine · 2022Review
- Chronic 3D Vascular-Immune Interface Established by Coculturing Pressurized Resistance Arteries and Immune Cells.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Angiotensin-(1-7)-A Potential Remedy for AKI: Insights Derived from the COVID-19 Pandemic.Journal of clinical medicine · 2021Review
- IL-10 treatment decreases blood pressure in male, but not female, spontaneously hypertensive rats.American journal of physiology. Renal physiology · 2020Article
- Toll-Like Receptors Contribute to Sex Differences in Blood Pressure Regulation.Journal of cardiovascular pharmacology · 2020Review
- Hypertensive female Sprague-Dawley rats require an intact nitric oxide synthase system for compensatory increases in renal regulatory T cells.American journal of physiology. Renal physiology · 2020Article
- Greater T Regulatory Cells in Females Attenuate DOCA-Salt-Induced Increases in Blood Pressure Versus Males.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Sex Differences in Kidney Function and Metabolism Assessed Using Hyperpolarized [1-Tomography (Ann Arbor, Mich.) · 2020Article
- Menopause and FOXP3American journal of physiology. Heart and circulatory physiology · 2019Article
- Immune mechanisms of hypertension.Nature reviews. Immunology · 2019Review
- Sex differences in the metabolic effects of the renin-angiotensin system.Biology of sex differences · 2019Review
- Animal Models of Hypertension: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2019Review
- High-fat diet-induced hypertension is associated with a proinflammatory T cell profile in male and female Dahl salt-sensitive rats.American journal of physiology. Heart and circulatory physiology · 2018Article
- Sex Differences in Hypertension: Where We Have Been and Where We Are Going.American journal of hypertension · 2018Review
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5 authors at 1 institution in 1 country.
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Abstract
Recent studies suggest that sex of the animal and T cell impact ANG II hypertension in Rag(-/-) mice, with females being protected relative to males. This study tested the hypothesis that ANG II results in greater increases in proinflammatory T cells and cytokines in males than in females. Male and female Sprague-Dawley (SD) rats, aged 12 wk, were treated with vehicle or ANG II (200 ng·kg(-1)·min(-1)) for 2 wk. Renal CD4(+) T cells and Tregs were comparable between vehicle-treated males and females, although males expressed more Th17 and IL-17(+) T cells and fewer IL-10(+) T cells than females. ANG II resulted in greater increases in CD4(+) T cells, Th17 cells, and IL-17(+) cells in males; Tregs increased only in females. We previously showed that ANG (1-7) antagonizes ANG II-induced increases in blood pressure in females and ANG (1-7) has been suggested to be anti-inflammatory. Renal ANG (1-7) levels were greater in female SD at baseline and following ANG II infusion. Additional rats were treated with ANG II plus the ANG (1-7)-mas receptor antagonist A-779 (48 μg·kg(-1)·h(-1)) to test the hypothesis that greater ANG (1-7) in females results in more Tregs relative to males. Inhibition of ANG (1-7) did not alter renal T cells in either sex. In conclusion, ANG II induces a sex-specific effect on the renal T cell profile. Males have greater increases in proinflammatory T cells, and females have greater increases in anti-inflammatory Tregs; however, sex differences in the renal T cell profile are not mediated by ANG (1-7).
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