ArticleGene therapy2015
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin.
Article in Gene therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Collagen-producing eye cell atlas reveals distinct fibroblast fates in early injury vs. fibrotic subretinal disease.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Potential of autophagy in subretinal fibrosis in neovascular age-related macular degeneration.Cellular & molecular biology letters · 2025Review
- Intracellular Signaling Pathways and Their Potential Targeting for Treatment of Ocular Posterior Segment Fibrosis.Journal of ophthalmic & vision research · 2025Review
- Rhodopsin-positive cell production by intravitreal injection of small molecule compounds in mouse models of retinal degeneration.PloS one · 2023Article
- Subretinal fibrosis in neovascular age-related macular degeneration: current concepts, therapeutic avenues, and future perspectives.Cell and tissue research · 2022Review
- Article
- Tengdan Capsule Prevents Hypertensive Kidney Damage in SHR by Inhibiting Periostin-Mediated Renal Fibrosis.Frontiers in pharmacology · 2021Article
- Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy.Scientific reports · 2020Article
- Increased expression of periostin and tenascin-C in eyes with neovascular glaucoma secondary to PDR.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Involvement of lncRNAs and Macrophages: Potential Regulatory Link to Angiogenesis.Journal of immunology research · 2020Review
- Altered Long Non-coding RNAs Involved in Immunological Regulation and Associated with Choroidal Neovascularization in Mice.International journal of medical sciences · 2020Article
- Attenuation of periostin in retinal Müller glia by TNF-α and IFN-γ.International journal of ophthalmology · 2019Article
- Periostin function in communication with extracellular matrices.Journal of cell communication and signaling · 2018Review
- Periostin in vitreoretinal diseases.Cellular and molecular life sciences : CMLS · 2017Review
- Periostin and its interacting proteins in the construction of extracellular architectures.Cellular and molecular life sciences : CMLS · 2017Review
- Periostin in kidney diseases.Cellular and molecular life sciences : CMLS · 2017Review
- A Novel Single-Strand RNAi Therapeutic Agent Targeting the (Pro)renin Receptor Suppresses Ocular Inflammation.Molecular therapy. Nucleic acids · 2017Article
- Different distributions of M1 and M2 macrophages in a mouse model of laser-induced choroidal neovascularization.Molecular medicine reports · 2017Article
- Therapeutic Effect of Novel Single-Stranded RNAi Agent Targeting Periostin in Eyes with Retinal Neovascularization.Molecular therapy. Nucleic acids · 2017Article
- Tenascin-C secreted by transdifferentiated retinal pigment epithelial cells promotes choroidal neovascularization via integrin αV.Laboratory investigation; a journal of technical methods and pathology · 2016Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related macular degeneration (AMD) is a vision-threatening disease characterized by choroidal fibrovascular membrane (FVM) formation, choroidal neovascularization (CNV) and choroidal fibrosis. No safe and effective therapeutic method has been developed for the choroidal fibrosis, although anti-vascular endothelial growth factor therapy can partially shrink the CNV. We recently reported that periostin (POSTN), which is produced by retinal pigment epithelial cells, has an important role in the formation of preretinal FVMs, but its role in choroidal FVMs has not been determined. In this study, we used Postn knockout mice to investigate the role played by POSTN in choroidal FVM formation. In addition, we used a new class of RNA interference (RNAi) agent (NK0144) that targets POSTN and determined its effect on choroidal FVM development. Genetic ablation of Postn had an inhibitory effect not only on CNV formation but also on choroidal fibrosis in a mouse CNV model. NK0144 also had a greater inhibitory effect on both the CNV and choroidal fibrosis than control RNAi with no apparent adverse effects. These findings suggest a causal relationship between POSTN and choroidal FVM formation, and also a potential therapeutic role of intravitreal NK0144 for AMD.
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