ArticleCancer research2015
Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway.
Article in Cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Chronic multifocal collagenous fibroma with tumor development at surgical incision site: a 46-year case report.Discover oncology · 2026Article
- Case Report: Osteosarcoma following traumatic injury in a juvenile Argentine black and white tegu (Frontiers in veterinary science · 2026Article
- Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas.Cancer cell · 2025Article
- Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma.Current issues in molecular biology · 2023Article
- Mechanical compression creates a quiescent muscle stem cell niche.Communications biology · 2023Article
- Case Report: Inguinal Myxofibrosarcoma Arising From the Surgical Site of Resected Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19.World journal of oncology · 2021Article
- Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models.Scientific reports · 2021Article
- Hepatocyte growth factor intervention to reduce myocardial injury and improve cardiac function on diabetic myocardial infarction rats.European journal of histochemistry : EJH · 2020Article
- Association of hemoglobin concentration with handgrip strength in relation to hepatocyte growth factor levels among elderly Japanese men aged 60-69 years: a cross-sectional study.Environmental health and preventive medicine · 2018Article
- Injury promotes sarcoma development in a genetically and temporally restricted manner.JCI insight · 2018Article
- Impact of intramuscular administration of lipid-soluble and water-soluble vehicles into regenerating muscle at the distinct phases of skeletal muscle regeneration.The journal of physiological sciences : JPS · 2018Article
- Acute Trauma Precipitating the Onset of Chest Wall Myxofibrosarcoma.Indian journal of surgical oncology · 2018Article
- Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors.Cancer cell · 2018Article
- Paracrine osteoprotegerin and β-catenin stabilization support synovial sarcomagenesis in periosteal cells.The Journal of clinical investigation · 2018Article
- Soft-Tissue Sarcoma following Traumatic Injury: Case Report and Review of the Literature.Frontiers in oncology · 2017Article
- Article
- HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.Radiation research · 2015Article
- Is there an Association between Trauma and Musculoskeletal Tumours? A Review of the Literature.Strategies in trauma and limb reconstructionReview
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Some patients with soft-tissue sarcoma (STS) report a history of injury at the site of their tumor. Although this phenomenon is widely reported, there are relatively few experimental systems that have directly assessed the role of injury in sarcoma formation. We recently described a mouse model of STS whereby p53 is deleted and oncogenic Kras is activated in muscle satellite cells via a Pax7(CreER) driver following intraperitoneal injection with tamoxifen. Here, we report that after systemic injection of tamoxifen, the vast majority of Pax7-expressing cells remain quiescent despite mutation of p53 and Kras. The fate of these muscle progenitors is dramatically altered by tissue injury, which leads to faster kinetics of sarcoma formation. In adult muscle, quiescent satellite cells will transition into an active state in response to hepatocyte growth factor (HGF). We show that modulating satellite cell quiescence via intramuscular injection of HGF increases the penetrance of sarcoma formation at the site of injection, which is dependent on its cognate receptor c-MET. Unexpectedly, the tumor-promoting effect of tissue injury also requires c-Met. These results reveal a mechanism by which HGF/c-MET signaling promotes tumor formation after tissue injury in a mouse model of primary STS, and they may explain why some patients develop a STS at the site of injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.