Evidence map›Paper›PMID 25503498›Full record

ReviewGenetics in medicine : official journal of the American College of Medical Genetics2015

Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society.

Sumit Parikh, Amy Goldstein, Mary Kay Koenig, Fernando Scaglia, Gregory M Enns, Russell Saneto, Irina Anselm, Bruce H Cohen, Marni J Falk, Carol Greene and 9 more

Registry-linked trialAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Genetics in medicine : official journal of the American College of Medical Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04543968 (Open Label Pilot Study Using Hydroxytyrosol), which is not on this map. Cited by 279 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
279citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04543968 nacompletednot on this mapstarted 2022, after this paper: background citation

Open Label Pilot Study Using Hydroxytyrosol (HT) as a Dietary Supplement in Patients With Mitochondrial Diseases (MDs)

TypeinterventionalSponsorHong Kong Children's HospitalRan2022 to 2024Enrolled10ConditionsMitochondrial DiseasesArmshydroxytyrosol (HT) intake, hydroxytyrosol (HT) intake and withdraw
3 · Its place in the literature

Who cites it

279 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  5. Metabolomic profiles of being physically active and less sedentary: a critical review.Metabolomics : Official journal of the Metabolomic Society · 2021
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219 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sumit ParikhDepartment of Neurology, Center for Child Neurology, Cleveland Clinic Children's Hospital, Cleveland, Ohio, USA.ORCID http://orcid.org/0000-0003-3712-8959
Amy GoldsteinDepartment of Pediatrics, Division of Child Neurology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID http://orcid.org/0000-0002-7675-3063
Mary Kay KoenigDepartment of Pediatrics, Division of Child and Adolescent Neurology, University of Texas Medical School at Houston, Houston, Texas, USA.ORCID http://orcid.org/0000-0001-5126-8515
Fernando ScagliaDepartment of Molecular and Human Genetics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
Gregory M EnnsDepartment of Pediatrics, Division of Medical Genetics, Stanford University Lucile Packard Children's Hospital, Palo Alto, California, USA.
Russell SanetoDepartment of Neurology, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA.
Irina AnselmDepartment of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA.
Bruce H CohenDepartment of Pediatrics, NeuroDevelopmental Science Center, Children's Hospital Medical Center of Akron, Akron, Ohio, USA.
Marni J FalkDivision of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Carol GreeneDepartment of Pediatrics, University of Maryland Medical Center, Baltimore, Maryland, USA.
Andrea L GropmanDepartment of Neurology, Children's National Medical Center and the George Washington University of the Health Sciences, Washington, DC, USA.
Richard HaasDepartment of Neurosciences and Pediatrics, UCSD Medical Center and Rady Children's Hospital San Diego, La Jolla, California, USA.
Michio HiranoDepartment of Neurology, Columbia University Medical Center, New York, New York, USA.
Phil MorganDepartment of Anesthesiology, Seattle Children's Hospital, Seattle, Washington, USA.
Katherine SimsDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA.
Mark TarnopolskyDepartment of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada.
Johan L K Van HoveDepartment of Pediatrics, Clinical Genetics and Metabolism, Children's Hospital Colorado, Denver, Colorado, USA.
Lynne WolfeNational Institutes of Health, Bethesda, Maryland, USA.
Salvatore DiMauroDepartment of Neurology, Columbia University Medical Center, New York, New York, USA.

Funding

The North American Mitochondrial Disease Consortium (NAMDC)U54NS078059 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HIRANO, MICHIO · 2011 to 2023
$17.5M
Tech-CoreP01HD080642 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUINZII, CATARINA M. · 2014 to 2018
$7.8M
NICHD NIH HHS P01 HD080642NINDS NIH HHS U54 NS078059
6 · The paper itself

Abstract

purposeThe purpose of this statement is to review the literature regarding mitochondrial disease and to provide recommendations for optimal diagnosis and treatment. This statement is intended for physicians who are engaged in diagnosing and treating these patients.

methodsThe Writing Group members were appointed by the Mitochondrial Medicine Society. The panel included members with expertise in several different areas. The panel members utilized a comprehensive review of the literature, surveys, and the Delphi method to reach consensus. We anticipate that this statement will need to be updated as the field continues to evolve.

resultsConsensus-based recommendations are provided for the diagnosis and treatment of mitochondrial disease.

conclusionThe Delphi process enabled the formation of consensus-based recommendations. We hope that these recommendations will help standardize the evaluation, diagnosis, and care of patients with suspected or demonstrated mitochondrial disease.

Indexed as

ConsensusDelphi TechniqueEvidence-Based MedicineHumansMitochondrial DiseasesTreatment Outcome

Identifiers

PMID25503498
PMCPMC5000852

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.