ArticleLipids2015
Oxidized low-density lipoprotein inhibits THP-1-derived macrophage autophagy via TET2 down-regulation.
Article in Lipids, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Review
- TET2 confers a mechanistic link of microRNA-210 and mtROS in hypoxia-suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep.The Journal of physiology · 2023Article
- KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy.Experimental and therapeutic medicine · 2022Article
- MiR-3571 modulates the proliferation and migration of vascular smooth muscle cells by targeting claudin 1.International journal of medical sciences · 2022Article
- The Epigenome in Atherosclerosis.Handbook of experimental pharmacology · 2022Article
- A bibliometric analysis of autophagy in atherosclerosis from 2012 to 2021.Frontiers in pharmacology · 2022Article
- Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure.Clinical science (London, England : 1979) · 2021Review
- Paeonol suppresses the effect of ox-LDL on mice vascular endothelial cells by regulating miR-338-3p/TET2 axis in atherosclerosis.Molecular and cellular biochemistry · 2020Article
- Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy PathwayFrontiers in pharmacology · 2020Article
- TET2: A Novel Epigenetic Regulator and Potential Intervention Target for Atherosclerosis.DNA and cell biology · 2018Review
- Activation of CD137 Signaling Enhances Vascular Calcification through c-Jun N-Terminal Kinase-Dependent Disruption of Autophagic Flux.Mediators of inflammation · 2018Article
- TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/HFrontiers in pharmacology · 2017Article
- Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE-/- mice.Oncotarget · 2016Article
- Subtype-specific effects of clonal hematopoiesis on cerebrovascular and cardiometabolic disease risk.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidized low-density lipoprotein (ox-LDL) is an independent risk factor of atherosclerosis. However, the mechanism underlying its pro-atherosclerosis roles has not yet been well explored. DNA demethylation modification, via DNA methyltransferases or ten-eleven-translocation (TET) family, is a crisis epigenetic regulation for various biological and pathological processes. This study aimed to investigate the effects of ox-LDL on macrophage autophagy and its potential epigenetic mechanism. Results showed that after treatment with 0, 10, 20, 40 or 80 mg/L ox-LDL for 24 h, the autophagy markers Beclin 1 and LC3 expression were obviously decreased at protein levels (P < 0.05). The mRNA and protein expression of TET2 was evidently decreased (P < 0.05). After pre-treatment with TET2 siRNA, the mRNA and protein levels of Beclin 1 and LC3 decreased compared with the 80 mg/L treatment group (P < 0.01). The mRNA and protein levels of Beclin 1 and LC3-II were up-regulated (P < 0.05) in the 5-aza-2'-deoxycytidine (a DNA methyltransferase inhibitor) of pretreatment group. Consistent with the Western blot results, cell immunofluorescence showed that the protein concentration of LC3-II decreased in the TET2 siRNA group and increased in the 5-aza-2'-deoxycytidine group. Taken together, these results showed that DNA demethylation modifications regulate ox-LDL-treated THP-1 macrophages autophagy and TET2 might be a novel regulator.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.