SynthesisPloS one2014
Efficacy of continuous positive airway pressure on testosterone in men with obstructive sleep apnea: a meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring.Sleep · 2023Pooled it
- Late-onset and functional hypogonadism in aging men: an integrated perspective on hormonal, sleep, and metabolic dimensions.Journal of endocrinological investigation · 2026Review
- The Role of Obstructive Sleep Apnea and CPAP Therapy in the Functional Hypogonadism of Male Patients With Severe Obesity.The Journal of clinical endocrinology and metabolism · 2026Article
- Review
- Reply: Exploring the Role of Testosterone in the Differential Outcomes of Continuous Positive Airway Pressure and Glucagon-like peptide 1 Treatments in Obstructive Sleep Apnea.Annals of the American Thoracic Society · 2024Article
- Sleep apnea syndrome associated with gonadal hormone imbalance (Review).Biomedical reports · 2023Review
- How is Obstructive Sleep Apnea Associated with High Blood Pressure and Diabetes Mellitus Type 2? Clues from a Two-Step Mendelian Randomized Study.Nature and science of sleep · 2023Article
- Sleep, testosterone and cortisol balance, and ageing men.Reviews in endocrine & metabolic disorders · 2022Review
- Sleep and the Testis.Current opinion in endocrine and metabolic research · 2021Article
- Serum testosterone/cortisol ratio in people with obstructive sleep apnea.Journal of clinical laboratory analysis · 2020Article
- A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations, and Future Research.The Journal of clinical endocrinology and metabolism · 2019Review
- Hypogonadotropic Hypogonadism in Men With Diabesity.Diabetes care · 2018Review
- Obstructive sleep apnea and hormones - a novel insight.Archives of medical science : AMS · 2017Article
- A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management.The Journal of clinical endocrinology and metabolism · 2017Review
- Sleep apnea syndrome in endocrine clinics.Journal of endocrinological investigation · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the efficacy of continuous positive airway pressure (CPAP) on serum testosterone in men with obstructive sleep apnea (OSA).
methodsTwo reviewers independently searched PubMed, Cochrane library, Embase and Web of Science before June 2014. Information on characteristics of subjects, study design, pre- and post-CPAP treatment of serum total testosterone, free testosterone and sexual hormone blinding protein (SHBG) was extracted for analysis.
resultsA total of 7 studies with 9 cohorts that included 232 men were pooled into meta-analysis. There was no change of total testosterone levels before and after CPAP treatment in OSA men (standardized mean difference (SMD) = -0.14, 95%CI: -0.63 to 0.34, z = 0.59, p = 0.558), even subdivided by CPAP therapeutic duration (>3 months). Meanwhile, no significant differences in free testosterone and SHBG were detected after CPAP treatment (SMD = 0.16, 95%CI: -0.09 to 0.40, z = 1.25, p = 0.211 and SMD = -0.58, 95%CI: -1.30 to 0.14, z = 1.59, p = 0.112, respectively).
conclusionCPAP has no influence on testosterone levels in men with OSA, further large-scale, well-design interventional investigation is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.