Evidence map›Paper›PMID 25503071›Full record

SynthesisInternational journal of geriatric psychiatry2015

Preoperative risk factors for postoperative delirium following hip fracture repair: a systematic review.

Esther S Oh, Meng Li, Tolulope M Fafowora, Sharon K Inouye, Cathy H Chen, Lori M Rosman, Constantine G Lyketsos, Frederick E Sieber, Milo A Puhan

Registry-linked trialOpen access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of geriatric psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04451538 (Impact of Perioperative Nutritional Intervention on Perioperative Outcomes of Elderly Patients Having Hip Fracture Surgery), which is not on this map. Cited by 75 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 5 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04451538 naterminatednot on this mapstarted 2020, after this paper: background citation

Impact of Perioperative Nutritional Intervention on Perioperative Outcomes of Elderly Patients Having Hip Fracture Surgery: A Randomized Control Trial

TypeinterventionalSponsorPeking University First HospitalRan2020 to 2021Enrolled30ConditionsElderly Patients, Malnutrition, Hip Fractures, Nutritional InterventionArmsNutritional intervention group, Control group
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 5 syntheses or guidelines pooled it, 158 citations in OpenAlex.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 2 countries.

Esther S OhDepartment of Medicine, John Hopkins University School of Medicine, Baltimore, MD, USA.
Meng LiPharmaceutical Outcomes Research & Policy Program, University of Washington, Seattle, WA, USA.
Tolulope M FafoworaDepartment of Medicine, John Hopkins University School of Medicine, Baltimore, MD, USA.
Sharon K InouyeAging Brain Center, Institute of Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Cathy H ChenPrinceton University, Princeton, NJ, USA.
Lori M RosmanDepartment of Welch Medical Library, John Hopkins University School of Medicine, Baltimore, MD, USA.
Constantine G LyketsosDepartment of Psychiatry and Behavioral Sciences, John Hopkins University School of Medicine, Baltimore, MD, USA.
Frederick E SieberDepartment of Anesthesiology and Critical Care Medicine, John Hopkins University School of Medicine, Baltimore, MD, USA.
Milo A PuhanJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Johns Hopkins Medicine · USBehavioral Pharma (United States) · USHebrew SeniorLife · USInstitute of Social and Preventive Medicine · CHJohns Hopkins Bayview Medical Center · USJohns Hopkins University · USPrinceton University · USUniversity of Washington · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI LYKETSOS, CONSTANTINE G · 1985 to 2019
$37.6M
Institute for Clinical and Translational Research (KL2)KL2RR025006 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$12.9M
CSF predictors of postoperative delirium in non-demented hip fracture patientsK23AG043504 · NIA · JOHNS HOPKINS UNIVERSITY · PI OH, ESTHER SEUNGHEE · 2012 to 2016
$819k
K07 Leadership GrantK07AG041835 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2013 to 2017
$656k
Oral Glucose Tolerance Test for Alzheimer's Disease Biomarker DevelopmentR21AG033769 · NIA · JOHNS HOPKINS UNIVERSITY · PI CRAFT, SUZANNE, OH, ESTHER SEUNGHEE · 2010 to 2011
$368k
NCATS NIH HHS UL1 TR 001079NCATS NIH HHS UL1 TR001079NCRR NIH HHS 5KL2RR025006NCRR NIH HHS KL2 RR025006NIA NIH HHS 1K23AG043504-01NIA NIH HHS K07 AG041835NIA NIH HHS K07AG041835NIA NIH HHS K23 AG043504NIA NIH HHS P50 AG005146NIA NIH HHS R21 AG033769NIA NIH HHS R21AG0337695PHS HHS UB4HP19193-03
6 · The paper itself

Abstract

objectiveSystematically identify preoperative clinical risk factors for incident postoperative delirium in individuals undergoing hip fracture repair in order to guide clinicians in identifying high risk patients at admission.

methodsThis is a systematic review of prospective observational studies with estimation of association between preoperative risk factors and incident postoperative delirium in multivariate models. Electronic searches were conducted in PubMed, Embase, PsycINFO, CINAHL, Cochrane Library, Proquest Dissertations and Theses, and WorldCatDissertations. Hand searches were conducted in selected journals and their supplements.

resultsSearch yielded 6380 titles and abstracts from electronic databases and 72 titles from hand searches, and 10 studies met inclusion criteria. The following risk factors were significant in bivariate models: cognitive impairment, age, gender, institutionalization, functional impairment, body mass index (BMI), albumin, comorbidities, American Society of Anesthesiologist classification, acute medical conditions, polypharmacy, and vision impairment. Among all of these risk factors, cognitive impairment most consistently remained statistically significant after adjusting for other risk factors in multivariate models, followed by BMI/albumin and multiple comorbidities.

conclusionIn our systematic review, cognitive impairment was one of the strongest preoperative risk factors for postoperative delirium after hip fracture surgery. Preoperative cognitive assessment may be one of the most useful methods of identifying those who are at high risk for postoperative delirium and prioritizing delivery of delirium prevention measures.

Indexed as

Cognition DisordersComorbidityDeliriumHip FracturesHumansIncidenceMultivariate AnalysisPostoperative ComplicationsProspective StudiesRisk Factorsdeliriumhip fracturepostoperativerisk factors

Identifiers

PMID25503071
PMCPMC4465414
OpenAlexW1569206101

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.