Evidence map›Paper›PMID 25503031›Full record

ArticleOptics letters2014

Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments.

Benquan Wang, Qiuxiang Zhang, Rongwen Lu, Yanan Zhi, Xincheng Yao

Abstract read
In one paragraph

Article in Optics letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Functional optical coherence tomography enablesBiomedical optics express · 2020
    Article
  5. Review
  6. Article
  7. Differential detection of retinal directionality.Biomedical optics express · 2018
    Article
  8. Functional optical coherence tomography of retinal photoreceptors.Experimental biology and medicine (Maywood, N.J.) · 2018
    Review
  9. Article
  10. Comparative investigation of stimulus-evoked rod outer segment movement and retinal electrophysiological activity.Proceedings of SPIE--the International Society for Optical Engineering · 2017
    Article
  11. Article
  12. Article
  13. Concurrent OCT imaging of stimulus evoked retinal neural activation and hemodynamic responses.Proceedings of SPIE--the International Society for Optical Engineering · 2017
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Biophysical mechanism of transient retinal phototropism in rod photoreceptors.Proceedings of SPIE--the International Society for Optical Engineering · 2016
    Article
  19. Proceedings of SPIE--the International Society for Optical Engineering · 2016
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Benquan Wang
Qiuxiang Zhang
Rongwen Lu
Yanan Zhi
Xincheng Yao
University of Alabama at Birmingham · US

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
Functional imaging of retinal photoreceptorsR01EY023522 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YAO, XINCHENG · 2014 to 2024
$3.5M
Super-resolution ophthalmoscopy for in vivo retinal imagingR01EY024628 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YAO, XINCHENG · 2014 to 2016
$1.1M
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY023522NEI NIH HHS R01 EY024628
6 · The paper itself

Abstract

Dynamic near infrared microscopy has revealed transient retinal phototropism (TRP) correlated with oblique light stimulation. Here, by developing a hybrid confocal microscopy and optical coherence tomography (OCT), we tested sub-cellular source of the TRP in living frog retina. Dynamic confocal microscopy and OCT consistently revealed photoreceptor outer segments as the anatomic source of the TRP. Further investigation of the TRP can provide insights in better understanding of Stiles-Crawford effect (SCE) on rod and cone systems, and may also promise an intrinsic biomarker for early detection of eye diseases that can produce photoreceptor dysfunction.

Indexed as

LightTomography, Optical CoherenceAnimalsAnuraFeasibility StudiesRetinal Photoreceptor Cell Outer Segment

Identifiers

PMID25503031
PMCPMC4428573
OpenAlexW1996362309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.