Trial reportJournal of Parkinson's disease2015
Dopaminergic modulation of arm swing during gait among Parkinson's disease patients.
Trial report in Journal of Parkinson's disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06816810 (TALLman Family Energizes Research To Help Alleviate Neuroinflammation in Parkinson's Disease - "TALLER THAN PD." A Phase 2 Futility Study to Evaluate the Efficacy, Safety and Tolerability of Hydroxychloroquine in Subjects With Early Treated Parkinson's Disease), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TALLman Family Energizes Research To Help Alleviate Neuroinflammation in Parkinson's Disease - "TALLER THAN PD." A Phase 2 Futility Study to Evaluate the Efficacy, Safety and Tolerability of Hydroxychloroquine in Subjects With Early Treated Parkinson's Disease
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Clinical assessment of upper limb impairments and functional capacity in Parkinson's disease: a systematic review.Arquivos de neuro-psiquiatria · 2023Pooled it
- Effect of rhythmic auditory cueing on parkinsonian gait: A systematic review and meta-analysis.Scientific reports · 2018Pooled it
- Abnormal arm swing movements in Parkinson's disease: onset, progression and response to L-Dopa.Journal of neuroengineering and rehabilitation · 2025Article
- Quantifying arm swing in Parkinson's disease: a method accounting for arm activities during free-living gait.Journal of neuroengineering and rehabilitation · 2025Article
- No evidence for effects of low-intensity vestibular noise stimulation on mild-to-moderate gait impairments in patients with Parkinson's disease.Journal of neurology · 2024Article
- Wearable sensor-based quantitative gait analysis in Parkinson's disease patients with different motor subtypes.NPJ digital medicine · 2024Article
- Arm Swing while Walking and Running: A New Clinical Feature to Separate Parkinson's Disease from Functional Parkinsonism.Movement disorders clinical practice · 2024Article
- The effect of dopaminergic treatment on whole body kinematics explored through network theory.Scientific reports · 2024Article
- Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study.Journal of Parkinson's disease · 2024Article
- Carpets with visual cues can improve gait in Parkinson's disease patients: may be independent of executive function.European journal of medical research · 2023Article
- Overview on wearable sensors for the management of Parkinson's disease.NPJ Parkinson's disease · 2023Review
- Predicting Ambulatory Capacity in Parkinson's Disease to Analyze Progression, Biomarkers, and Trial Design.Movement disorders : official journal of the Movement Disorder Society · 2023Observational
- A novel clinical sign to assess the risk of Parkinson's disease in patients with isolated asymmetric arm swing.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Article
- Evaluation of Arm Swing Features and Asymmetry during Gait in Parkinson's Disease Using the Azure Kinect Sensor.Sensors (Basel, Switzerland) · 2022Article
- Proof of Concept in Artificial-Intelligence-Based Wearable Gait Monitoring for Parkinson's Disease Management Optimization.Biosensors · 2022Article
- Troubleshooting Gait Disturbances in Parkinson's Disease With Deep Brain Stimulation.Frontiers in human neuroscience · 2022Review
- Arm swing responsiveness to dopaminergic medication in Parkinson's disease depends on task complexity.NPJ Parkinson's disease · 2021Article
- Cholinergic Basal Forebrain Volumes Predict Gait Decline in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Mechanomyography and acceleration show interlimb asymmetries in Parkinson patients without tremor compared to controls during a unilateral motor task.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundReduced arm swing amplitude, symmetry, and coordination during gait have been reported in Parkinson's disease (PD), but the relationship between dopaminergic depletion and these upper limb gait changes remains unclear.
objectiveWe aimed to investigate the effects of dopaminergic drugs on arm swing velocity, symmetry, and coordination in PD.
methodsForearm angular velocity was recorded in 16 PD and 17 control subjects (Controls) during free walking trials. Angular velocity amplitude of each arm, arm swing asymmetry, and maximum cross-correlation were compared between control and PD groups, and between OFF- and ON-medication states among PD subjects.
resultsCompared to Controls, PD subjects in the OFF-medication state exhibited lower angular velocity amplitude of the slower- (p = 0.0018), but not faster- (p = 0.2801) swinging arm. In addition, PD subjects demonstrated increased arm swing asymmetry (p = 0.0046) and lower maximum cross-correlation (p = 0.0026). Following dopaminergic treatment, angular velocity amplitude increased in the slower- (p = 0.0182), but not faster- (p = 0.2312) swinging arm among PD subjects. Furthermore, arm swing asymmetry decreased (p = 0.0386), whereas maximum cross-correlation showed no change (p = 0.7436). Pre-drug angular velocity amplitude of the slower-swinging arm was correlated inversely with the change in arm swing asymmetry (R = -0.73824, p = 0.0011).
conclusionsThis study provides quantitative evidence that reduced arm swing and symmetry in PD can be modulated by dopaminergic replacement. The lack of modulations of bilateral arm coordination suggests that additional neurotransmitters may also be involved in arm swing changes in PD. Further studies are warranted to investigate the longitudinal trajectory of arm swing dynamics throughout PD progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.