ArticleNature communications2014
Serotonergic neurons respond to nutrients and regulate the timing of steroid hormone biosynthesis in Drosophila.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism.Scientific reports · 2017Pooled it
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- Insulin and epidermal signals independently shape sexually dimorphic neurite branching in C. elegans.EMBO reports · 2025Article
- Photoperiodic plasticity of pigment-dispersing factor immunoreactive fibers projecting toward prothoracicotropic hormone neurons in flesh fly Sarcophaga similis larvae.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Parasitoid wasp venoms degradeScience advances · 2025Article
- Serotonergic modulation of swallowing in a complete fly vagus nerve connectome.Current biology : CB · 2024Article
- Developmental analysis of Spalt function in the Drosophila prothoracic gland.Development (Cambridge, England) · 2024Article
- The intestinal stem cell/enteroblast-GAL4 driver, escargot-GAL4, also manipulates gene expression in the juvenile hormone-synthesizing organ of Drosophila melanogaster.Scientific reports · 2024Article
- Hypoxia delays steroid-induced developmental maturation in Drosophila by suppressing EGF signaling.PLoS genetics · 2024Article
- NeuronalCells · 2023Article
- Serotonergic signaling plays a deeply conserved role in improving oocyte quality.Developmental biology · 2023Article
- Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum.Development (Cambridge, England) · 2023Article
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- Mammalian puberty: a fly perspective.The FEBS journal · 2023Review
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- Serotonergic neuron ribosomal proteins regulate the neuroendocrine control of Drosophila development.PLoS genetics · 2022Article
- Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila.Nature metabolism · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The temporal transition of development is flexibly coordinated in the context of the nutrient environment, and this coordination is essential for organisms to increase their survival fitness and reproductive success. Steroid hormone, a key player of the juvenile-to-adult transition, is biosynthesized in a nutrient-dependent manner; however, the underlying genetic mechanism remains unclear. Here we report that the biosynthesis of insect steroid hormone, ecdysteroid, is regulated by a subset of serotonergic neurons in Drosophila melanogaster. These neurons directly innervate the prothoracic gland (PG), an ecdysteroid-producing organ and share tracts with the stomatogastric nervous system. Interestingly, the projecting neurites morphologically respond to nutrient conditions. Moreover, reduced activity of the PG-innervating neurons or of serotonin signalling in the PG strongly correlates with a delayed developmental transition. Our results suggest that serotonergic neurons form a link between the external environment and the internal endocrine system by adaptively tuning the timing of steroid hormone biosynthesis.
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