Evidence map›Paper›PMID 25502615›Full record

ArticlePharmacogenetics and genomics2015

PharmGKB summary: ibuprofen pathways.

Liudmila L Mazaleuskaya, Katherine N Theken, Li Gong, Caroline F Thorn, Garret A FitzGerald, Russ B Altman, Teri E Klein

Registry-linked trialAbstract read
In one paragraph

Article in Pharmacogenetics and genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07400471 (The Effects of Preemptive Multimodal Analgesic on Endodontic Pain.), which is not on this map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07400471 early_phase1recruitingnot on this mapstarted 2026, after this paper: background citation

The Effects of Preemptive Multimodal Analgesic on Endodontic Pain.

TypeinterventionalSponsorChattogram International Dental CollegeRan2026 to 2027Enrolled280ConditionsPost Endodontic Pain, Mechanical Detection Threshold, Mechanical Pain Threshold, Mechanical Pain SensitivityArmsPregabalin- Acetaminophen, Duloxetine- Acetaminophen
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Effect of Ibuprofen on BrainAGE: A Randomized, Placebo-Controlled, Dose-Response Exploratory Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018
    Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Peptide-Based Approaches for Pain Relief and Healing in Wounds.International journal of molecular sciences · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liudmila L MazaleuskayaaDepartment of Systems Pharmacology and Translational Therapeutics bInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Departments of cGenetics dBioengineering, Stanford University, Stanford, California, USA.
Katherine N Theken
Li Gong
Caroline F Thorn
Garret A FitzGerald
Russ B Altman
Teri E Klein

Funding

POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
PharmGKB: pharmacogenomics knowledge for precision medicineR24GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO, KLEIN, TERI ELLEN · 2010 to 2018
$25.2M
Pilot Study: POPULATION PHARMACOLOGYU54HL117798 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2016
$18.5M
TRAINING GRANT IN HEMOSTASIS AND THROMBOSIST32HL007971 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Rodney M Camire · 2001 to 2026
$10.6M
Multidisciplinary Training in Cardiovascular BiologyT32HL007954 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DAVIES, PETER FRANCIS · 2000 to 2019
$9.9M
NHLBI NIH HHS HL007954NHLBI NIH HHS HL117798NHLBI NIH HHS T32 HL007954NHLBI NIH HHS T32 HL007971NHLBI NIH HHS U54 HL117798NIGMS NIH HHS R24 GM061374NLM NIH HHS T15 LM007033PHS HHS NIH/NIGMS R24 GM61374
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalIbuprofenPharmacogeneticsBiological TransportDrug InteractionsHumansInactivation, MetabolicKidneyLiverMetabolic Networks and PathwaysAnti-Inflammatory Agents, Non-SteroidalIbuprofen

Identifiers

PMID25502615
PMCPMC4355401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.