ArticlePLoS genetics2014
The miR9863 family regulates distinct Mla alleles in barley to attenuate NLR receptor-triggered disease resistance and cell-death signaling.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.
- What Do We Know about Barley miRNAs?International journal of molecular sciences · 2022Pooled it
- Purifying recombinant proteins from Nicotiana benthamiana for structural studies.Nature protocols · 2026Review
- TaELP2 Interacts With TaDCL1 and Negatively Regulates Wheat Resistance Against Stripe Rust.Molecular plant pathology · 2026Article
- Identification of MicroRNAs Involved in Different Layers of Rice-Magnaporthe oryzae Interaction.Rice (New York, N.Y.) · 2025Article
- Genome-wide identification, expression, and regulatory network analysis of wheat microRNAs responsive toFrontiers in plant science · 2025Article
- The biogenesis, regulation and functions of transitive siRNA in plants.Acta biochimica et biophysica Sinica · 2024Review
- Mechanism of Rice Resistance to Bacterial Leaf Blight via Phytohormones.Plants (Basel, Switzerland) · 2024Review
- Epigenetic weapons of plants against fungal pathogens.BMC plant biology · 2024Review
- Plant biomarkers as early detection tools in stress management in food crops: a review.Planta · 2024Review
- Two functional CC-NBS-LRR proteins from rye chromosome 6RS confer differential age-related powdery mildew resistance to wheat.Plant biotechnology journal · 2024Article
- Regulation of plant immunity via small RNA-mediated control of NLR expression.Journal of experimental botany · 2023Article
- Identification of miRNAs Involved in Maize-Induced Systemic Resistance Primed byJournal of fungi (Basel, Switzerland) · 2023Article
- Comprehensive, integrative genomic analysis of microRNA expression profiles in different tissues of two wheat cultivars with different traits.Functional & integrative genomics · 2022Article
- Fungal Secondary Metabolites and Small RNAs Enhance Pathogenicity during Plant-Fungal Pathogen Interactions.Journal of fungi (Basel, Switzerland) · 2022Review
- Plant Disease Resistance-Related Signaling Pathways: Recent Progress and Future Prospects.International journal of molecular sciences · 2022Review
- The master role of siRNAs in plant immunity.Molecular plant pathology · 2022Review
- Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems.Nature reviews. Molecular cell biology · 2022Review
- Heightened miR6024-NLR interactions facilitate necrotrophic pathogenesis in tomato.Plant molecular biology · 2022Article
- MicroRNA candidate miRcand137 in apple is induced by Botryosphaeria dothidea for impairing host defense.Plant physiology · 2022Article
- Role of phasiRNAs in plant-pathogen interactions: molecular perspectives and bioinformatics tools.Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Barley (Hordeum vulgare L.) Mla alleles encode coiled-coil (CC), nucleotide binding, leucine-rich repeat (NB-LRR) receptors that trigger isolate-specific immune responses against the powdery mildew fungus, Blumeria graminis f. sp. hordei (Bgh). How Mla or NB-LRR genes in grass species are regulated at post-transcriptional level is not clear. The microRNA family, miR9863, comprises four members that differentially regulate distinct Mla alleles in barley. We show that miR9863 members guide the cleavage of Mla1 transcripts in barley, and block or reduce the accumulation of MLA1 protein in the heterologous Nicotiana benthamiana expression system. Regulation specificity is determined by variation in a unique single-nucleotide-polymorphism (SNP) in mature miR9863 family members and two SNPs in the Mla miR9863-binding site that separates these alleles into three groups. Further, we demonstrate that 22-nt miR9863s trigger the biogenesis of 21-nt phased siRNAs (phasiRNAs) and together these sRNAs form a feed-forward regulation network for repressing the expression of group I Mla alleles. Overexpression of miR9863 members specifically attenuates MLA1, but not MLA10-triggered disease resistance and cell-death signaling. We propose a key role of the miR9863 family in dampening immune response signaling triggered by a group of MLA immune receptors in barley.
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