ArticleCerebrovascular diseases (Basel, Switzerland)2014
The role of carotid intima-media thickness in predicting longitudinal cognitive function in an older adult cohort.
Article in Cerebrovascular diseases (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intima Media Thickness and Cognitive Function Among Adults: Meta-Analysis of Observational and Longitudinal Studies.Journal of the American Heart Association · 2022Pooled it
- Impact of internal carotid artery thickness on postoperative cognitive function in cervical spondylotic myelopathy patients.BMC anesthesiology · 2025Article
- Temporal changes and implications of diffusion tensor imaging metrics and cerebral white matter volume in patients undergoing carotid endarterectomy - a prospective study.Neuroradiology · 2025Article
- Dissecting the vascular-cognitive nexus: energetic vs. conventional hemodynamic parameters.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Optimal cardiovascular health is associated with slower cognitive decline.European journal of neurology · 2024Article
- Association of Carotid Intima Media Thickening with Future Brain Region Specific Amyloid-β Burden.Journal of Alzheimer's disease : JAD · 2022Article
- Effect of age stratification on the association between carotid intima-media thickness and cognitive impairment in Chinese hypertensive patients: new insight from the secondary analysis of the China Stroke Primary Prevention Trial (CSPPT).Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders.Current topics in behavioral neurosciences · 2021Review
- Asymptomatic Carotid Disease and Cognitive Impairment: What Is the Evidence?Frontiers in neurology · 2021Review
- Carotid intima-media thickness relative to cognitive impairment in dialysis patients, and their relationship with brain volume and cerebral small vessel disease.Therapeutic advances in chronic disease · 2020Article
- Association Between Carotid Artery Intima-Media Thickness and Combinations of Mild Cognitive Impairment and Pre-Frailty in Older Adults.International journal of environmental research and public health · 2019Article
- Carotid Flow Velocities and Blood Pressures Are Independently Associated With Cognitive Function.American journal of hypertension · 2019Article
- Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort.BMC medicine · 2018Article
- Increased augmentation index and central systolic arterial pressure are associated with lower school and motor performance in young adolescents.The Journal of international medical research · 2017Article
- Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Ultrasound Markers of Carotid Atherosclerosis and Cognition: The Northern Manhattan Study.Stroke · 2017Article
- The Role of Sleeve Gastrectomy in Reducing Cardiovascular Risk.Obesity surgery · 2017Article
- The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study.Cerebrovascular diseases extra · 2017Article
- Carotid intima-media thickness and cognitive function in a middle-aged and older adult community: a cross-sectional study.Journal of neurology · 2016Article
- Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease.Biochimica et biophysica acta · 2016Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
background and purposeCarotid atherosclerosis is a risk factor for cerebrovascular disease in older adults. Although age-related cognitive decline has been associated with cerebrovascular disease, not much is known about the consequences of carotid atherosclerosis on longitudinal cognitive function. This study examines the longitudinal relationship between atherosclerosis and cognition in a sample of non-demented older subjects using baseline measurements of carotid intima media thickness (CIMT) and annual cognitive measures of executive function (EXEC) and verbal memory (MEM).
methodsBaseline measurements included CIMT derived from B-mode carotid artery ultrasound, structural T1-weighted images of white matter hypointensities (WMH), white matter lesions (WML), and cerebral infarct. Hypertension, low-density lipoprotein (LDL), diabetes, and waist to hip ratios (WHR) were included as covariates in our models to control for cerebrovascular risks and central adiposity. Annual composite scores of EXEC and MEM functions were derived from item response theory. Linear mixed models were used to model longitudinal cognitive change.
resultsA significant inverse relationship was found between baseline CIMT and annual EXEC score, but not annual MEM score. Subjects included in the highest 4th quartile of CIMT showed a rate of annual decline in EXEC score that was significant relative to subjects in lower quartile groups (p<0.01). The relationship between the 4th quartile of CIMT and annual EXEC score remained significant after independently adjusting for imaging measures of white matter injury and cerebral infarct.
conclusionsOlder adult subjects with the highest index of CIMT showed an annual decline in EXEC scores that was significant relative to subjects with lower quartile measurements of CIMT, independent of our measures of white matter injury and cerebral infarct. Our findings suggest that elevated measures of CIMT may mark an atherosclerotic state, resulting in a decline in executive function and not memory in non-demented older adults.
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