ArticleBehavior genetics2015
Genetic relationship between the addiction diagnosis in adults and their childhood measure of addiction liability.
Article in Behavior genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- The Concept of Resistance to Substance Use and a Research Approach: The Resist! Project.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2023Article
- The intermediary role of adolescent temperamental and behavioral traits on the prospective associations between polygenic risk and cannabis use among young adults of European Ancestry.Addiction (Abingdon, England) · 2021Article
- Forecasting Opioid Use Disorder at 25 Years of Age in 16-Year-Old Adolescents.The Journal of pediatrics · 2020Article
- Adolescent Behavioral Characteristics Mediate Familial Effects on Alcohol Use and Problems in College-Bound Students.Substance abuse : research and treatment · 2020Article
- Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study.Development and psychopathology · 2018Article
- Global white matter microstructural abnormalities associated with addiction liability score in drug naïve youth.Brain imaging and behavior · 2018Article
- Binge Eating Disorder (BED) in Relation to Addictive Behaviors and Personality Risk Factors.Frontiers in psychology · 2017Article
- Item Response Theory Analysis to Assess Dimensionality of Substance Use Disorder Abuse and Dependence Symptoms.International journal of person centered medicine · 2016Article
- Temperament disturbances measured in infancy progress to substance use disorder 20 years later.Personality and individual differences · 2015Article
- Longitudinal Modeling of the Association Between Transmissible Risk, Affect During Drug Use and Development of Substance Use Disorder.Journal of addiction medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Transmissible liability index (TLI), developed employing a high-risk design and item response theory, enables quantification of the latent trait of liability to drug use disorders (DUD) in children. TLI has been shown to have high heritability and predict DUD in young adulthood. This study extends prior research and determines the genetic contribution of DUD liability measured by TLI to adult liability as indexed by DUD diagnosis. The study utilizes data from a twin sample tracked from age 11 to age 25. In addition to confirming TLI's high heritability and predictive validity, it shows that the genetic component of variance in TLI assessed in childhood accounts for over half of the genetic variance in DUD diagnosis and the entire phenotypic relationship between the two liability measures. This validates TLI as an early measure of DUD liability and supports its utility in early-age genetic and other mechanistic studies of DUD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.