SynthesisDigestive diseases and sciences2015
Medical and surgical complications of inflammatory bowel disease in the elderly: a systematic review.
Synthesis in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Systematic Review and Meta-analysis: Phenotype and Clinical Outcomes of Older-onset Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2016Pooled it
- Functional outcomes following ileal pouch-anal anastomosis (IPAA) in older patients: a systematic review.International journal of colorectal disease · 2016Pooled it
- Efficacy of Intestinal Obstruction Catheter Combined with Modified Dachengqi Decoction in Elderly Patients with Early Postoperative Inflammatory Intestinal Obstruction: A Randomised Study.International journal of general medicine · 2026Article
- Current Perspectives on Indications for Ileal Pouch-Anal Anastomosis in Older Patients.Clinical and experimental gastroenterology · 2022Review
- Anti-inflammatory and antibacterial effects of human cathelicidin active fragment KR-12 in the mouse models of colitis: a novel potential therapy of inflammatory bowel diseases.Pharmacological reports : PR · 2021Article
- IBD in the Elderly: Management Challenges and Therapeutic Considerations.Current gastroenterology reports · 2019Review
- A Comprehensive Review of the Diagnosis and Pharmacological Management of Crohn's Disease in the Elderly Population.Drugs & aging · 2019Review
- Management of inflammatory bowel disease in older persons: evolving paradigms.Intestinal research · 2018Review
- Inflammatory Bowel Disease is Similar in Patients with Older Onset and Younger Onset.Inflammatory bowel diseases · 2017Observational
- Management of Inflammatory Bowel Disease in the Elderly.Current treatment options in gastroenterology · 2016Review
- Thiopurines in the Management of Crohn's Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity-A Retrospective Study.Canadian journal of gastroenterology & hepatology · 2016Article
- Diabetes and the risk of infections with immunomodulator therapy in inflammatory bowel diseases.Alimentary pharmacology & therapeutics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsThe complications of therapy, hospitalization, and surgery related to inflammatory bowel disease (IBD) in the elderly are not well described. While multiple reviews have described the management and complications of elderly patients with IBD, none have been performed in a systematic fashion.
methodsWe performed a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to evaluate the association between elderly patients with IBD and complications from therapy, hospitalizations, and surgery. Eligible studies were identified via structured keyword searches in PubMed and manual literature searches.
resultsA total of 5,644 publications were identified. Of these, fourteen studies met inclusion criteria, encompassing 963 elderly IBD patients (113 Crohn's disease and 850 ulcerative colitis patients), over 37,000 hospitalizations of elderly IBD patients and over 4,500 controls. Consistent associations were observed between increased age and higher nocturnal stool frequency post-ileal pouch anal anastomosis. Only two studies met inclusion criteria for medication-related complications, one observed an increased mortality and infection risk among elderly patients treated with tumor necrosis factor antagonists and the other observed increased hospital-related complications among elderly patients treated with steroids.
conclusionsElderly patients with IBD are at an increased risk of hospital- and therapy-related complications. We found a paucity of high-quality studies evaluating outcomes in elderly patients with IBD. Further studies of elderly patients with IBD are needed to further evaluate the effect of age on medical and surgical complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.