ArticleJournal of cell science2015
The septation initiation network controls the assembly of nodes containing Cdr2p for cytokinesis in fission yeast.
Article in Journal of cell science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Molecular Mechanism of Cytokinesis.Annual review of biochemistry · 2019Review
- NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.Current biology : CB · 2019Article
- Mechanisms of contractile ring tension production and constriction.Biophysical reviews · 2018Review
- Involvement of the septation initiation network in events during cytokinesis in fission yeast.Journal of cell science · 2018Article
- Analysis of interphase node proteins in fission yeast by quantitative and superresolution fluorescence microscopy.Molecular biology of the cell · 2017Article
- Cytokinesis in Metazoa and Fungi.Cold Spring Harbor perspectives in biology · 2017Review
- Nine unanswered questions about cytokinesis.The Journal of cell biology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the fission yeast Schizosaccharomyces pombe, cortical protein structures called interphase nodes help to prepare the cell for cytokinesis by positioning precursors of the cytokinetic contractile ring, and the septation initiation network (SIN) regulates the onset of cytokinesis and septum formation. Previous work has noted that one type of interphase node disappears during mitosis providing SIN activity is high. Here, we used time-lapse fluorescence microscopy to provide evidence that SIN activity is necessary and sufficient to disperse the type 1 node proteins Cdr2p and Mid1p into the cytoplasm, so these nodes assemble only during interphase through early mitosis when SIN activity is low. Activating the SIN in interphase cells dispersed Cdr2p and anillin Mid1p from type 1 nodes a few min after the SIN kinase Cdc7p–GFP accumulated at spindle pole bodies. If the SIN was then turned off in interphase cells, Cdr2p and Mid1p reappeared in nodes in parallel with the decline in SIN activity. Hyperactivating SIN during mitosis dispersed type 1 nodes earlier than normal, and prolonged SIN activation prevented nodes from reforming at the end of mitosis.
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Registered trials
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