Evidence map›Paper›PMID 25501508›Full record

ReviewTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015

Focusing on long noncoding RNA dysregulation in gastric cancer.

Lu Gan, Midie Xu, Yi Zhang, Xia Zhang, Weijian Guo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. RETRACTED: LncRNA ODRUL Contributes to Osteosarcoma Progression through the miR-3182/MMP2 AxisMolecular therapy : the journal of the American Society of Gene Therapy · 2017
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Prospero homeobox 1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017
    Article
  15. Article
  16. Decreased long noncoding RNA MIR31HG is correlated with poor prognosis and contributes to cell proliferation in gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  17. An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  18. Article
  19. Article
  20. Methylation status of TRAF2 is associated with the diagnosis and prognosis of gastric cancer.International journal of clinical and experimental pathology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Lu GanDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Midie Xu
Yi Zhang
Xia Zhang
Weijian Guo
Shanghai Medical College of Fudan University · CNFudan University Shanghai Cancer Center · CNPeople's Liberation Army 401 Hospital · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the discovery of functions of long noncoding RNA (lncRNA) HOTAIR lifts ncRNA to new levels, large numbers of research have been demonstrated for the roles of lncRNAs in diverse biological processes, such as development, cellular differentiation, and a wide range of diseases including cancer. And, recent studies have discovered that lncRNAs can participate in almost every step in the life cycle of gene regulation, including chromosome dosage compensation, imprinting, epigenetic regulation, nuclear and cytoplasmic trafficking, transcription, mRNA splicing, and translation, mainly in the four archetypes-signals, decoys, guides, and scaffolds. Unsurprisingly, accumulating studies have demonstrated that serious lncRNAs are dysregulated in gastric cancer (GC), one of the major causes of cancer-related mortality worldwide, and closely related to tumorigenesis, metastasis, or prognosis. In this review, we will discuss diverse functions of lncRNAs and highlight the growing evidence for the important roles of lncRNAs acting as biomarkers for the early diagnosis of GC, as indicators of GC prognosis, or even as therapeutic targets in GC.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsGene ExpressionHumansPrognosisRNA, Long NoncodingStomach NeoplasmsRNA, Long Noncoding

Identifiers

PMID25501508
OpenAlexW2008229895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.