ArticlePhysiological reports2014
Rates of carbon monoxide elimination in males and females.
Article in Physiological reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Multimodal intervention reduces seasonal carbon monoxide poisoning incidence and myocardial injury: a retrospective cohort study accounting for environmental temperature.BMC public health · 2026Article
- Validity of the Fagerström test for nicotine dependence among persons with intellectual disabilities: Cross-sectional evidence from the POWER PID study.Tobacco prevention & cessation · 2026Article
- Hypocapnia in acute carbon monoxide poisoning: A complex interaction beyond metabolic compensation.PloS one · 2026Article
- Hospitalization for carbon monoxide poisoning is associated with substance use and mood disorders.Internal and emergency medicine · 2025Article
- Burden of Carbon Monoxide Poisoning in Asian Countries From 1990 to 2021 and Its Projection Until 2030: An Analysis of the Global Burden of Disease Study 2021.Clinical epidemiology · 2025Article
- Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis of Cohort Studies.Psychiatry investigation · 2024Article
- Global, regional, and national mortality due to unintentional carbon monoxide poisoning, 2000-2021: results from the Global Burden of Disease Study 2021.The Lancet. Public health · 2023Article
- Carbon monoxide poisoning: beyond survival - mortality, morbidities, and risk factors, a Turkey sample.PeerJ · 2023Article
- Objective measure of smoking status highlights disparities by sex.American heart journal plus : cardiology research and practice · 2022Article
- Association between Early Phase Serum Lactate Levels and Occurrence of Delayed Neuropsychiatric Sequelae in Adult Patients with Acute Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2022Review
- Can Exhaled Carbon Monoxide Be Used as a Marker of Exposure? A Cross-Sectional Study in Young Adults.International journal of environmental research and public health · 2021Article
- Epidemiological Study of Carbon Monoxide Deaths in North Jordan 2009-2018.Materia socio-medica · 2021Article
- Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review.International journal of environmental research and public health · 2020Review
- A New Method to Improve Running Economy and Maximal Aerobic Power in Athletes: Endurance Training With Periodic Carbon Monoxide Inhalation.Frontiers in physiology · 2019Article
- Replicating measurements of total hemoglobin mass (tHb-mass) within a single day: precision of measurement; feasibility and safety of using oxygen to expedite carbon monoxide clearance.Physiological reports · 2018Article
- Clinical challenges facing patient participation in cardiac rehabilitation: cigarette smoking.Expert review of cardiovascular therapyReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to verify the previously reported shorter half-time of elimination (t½) of carbon monoxide (CO) in females compared to males. Seventeen healthy subjects (nine men) completed three sessions each, on separate days. For each session, subjects were exposed to CO to raise the carboxyhemoglobin percentage (COHb) to ~10%; then breathed in random order, either (a) 100% O2 at poikilocapnia (no CO2 added), or (b) hyperoxia while maintaining normocapnia using sequential gas delivery, or (c) voluntary hyperpnea at~4x the resting minute ventilation. We measured minute ventilation, hemoglobin concentration [Hb] and COHb at 5 min intervals. The half-time of reduction of COHb (t½) was calculated from serial blood samples. The total hemoglobin mass (HbTOT) was calculated from [Hb] and estimated blood volume from a nomogram based on gender, height, and weight. The t½ in the females was consistently shorter than in males in all protocols. This relationship was sustained even after controlling for alveolar ventilation (P < 0.05), with the largest differences in t½ between the genders occurring at low alveolar ventilation rates. However, when t½ was further normalized for HbTOT, there was no significant difference in t½ between genders at alveolar ventilation rates between 4 and 40 L/min (P = 0.24). We conclude that alveolar ventilation and HbTOT are sufficient to account for a major difference in CO clearance between genders under resting (nonexercising) conditions.
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