ArticleNature neuroscience2015
ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 133 citations in OpenAlex.
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- Sleep and wake markers of thalamocortical functioning in early-course psychosis and first-degree relatives.Schizophrenia (Heidelberg, Germany) · 2026Article
- Thalamic reticular neurons provide cell type-specific modulation of sound processing in the auditory thalamus.PLoS biology · 2026Article
- Neuronal Features of Visual Attention in the Mouse Superior Colliculus Depend on Learned Behavioral Relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Reticular thalamic hyperexcitability drives autism spectrum disorder behaviors in the Cntnap2 model of autism.Science advances · 2025Article
- Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus.Nature communications · 2025Article
- Actions of the antiseizure drug carbamazepine in the thalamic reticular nucleus: Potential mechanism of aggravating absence seizures.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A model of thalamo-cortical interaction for incremental binding in mental contour-tracing.PLoS computational biology · 2025Article
- Development of reciprocal connections between the dorsal lateral geniculate nucleus and the thalamic reticular nucleus.Neural development · 2024Article
- Distribution Patterns of Subgroups of Inhibitory Neurons Divided by Calbindin 1.Molecular neurobiology · 2023Article
- Targeting the Limbic System: Insights into Its Involvement in Tinnitus.International journal of molecular sciences · 2023Review
- Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner.Nature communications · 2023Article
- Generation of ventralized human thalamic organoids with thalamic reticular nucleus.Cell stem cell · 2023Article
- Diencephalic organoids - A key to unraveling development, connectivity, and pathology of the human diencephalon.Frontiers in cellular neuroscience · 2023Review
- Visual Deprivation Selectively Reduces Thalamic Reticular Nucleus-Mediated Inhibition of the Auditory Thalamus in Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Secondary thalamic neuroinflammation after focal cortical stroke and traumatic injury mirrors corticothalamic functional connectivity.The Journal of comparative neurology · 2022Article
- Developmental oxidative stress leads to T-type CaMolecular psychiatry · 2022Article
- Sex-Specific Stress-Related Behavioral Phenotypes and Central Amygdala Dysfunction in a Mouse Model of 16p11.2 Microdeletion.Biological psychiatry global open science · 2021Article
- Involvement of the thalamic reticular nucleus in prepulse inhibition of acoustic startle.Translational psychiatry · 2021Article
8 more citing papers are in PubMed but not listed here.
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10 authors at 3 institutions in 1 country.
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Abstract
Selective processing of behaviorally relevant sensory inputs against irrelevant ones is a fundamental cognitive function whose impairment has been implicated in major psychiatric disorders. It is known that the thalamic reticular nucleus (TRN) gates sensory information en route to the cortex, but the underlying mechanisms remain unclear. Here we show in mice that deficiency of the Erbb4 gene in somatostatin-expressing TRN neurons markedly alters behaviors that are dependent on sensory selection. Whereas the performance of the Erbb4-deficient mice in identifying targets from distractors was improved, their ability to switch attention between conflicting sensory cues was impaired. These behavioral changes were mediated by an enhanced cortical drive onto the TRN that promotes the TRN-mediated cortical feedback inhibition of thalamic neurons. Our results uncover a previously unknown role of ErbB4 in regulating cortico-TRN-thalamic circuit function. We propose that ErbB4 sets the sensitivity of the TRN to cortical inputs at levels that can support sensory selection while allowing behavioral flexibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.