ArticleNature communications2014
A tetrahelical DNA fold adopted by tandem repeats of alternating GGG and GCG tracts.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Structural basis of G-quadruplex recognition by a camelid antibody fragment.Nucleic acids research · 2025Article
- A sodium/potassium switch for G4-prone G/C-rich sequences.Nucleic acids research · 2024Article
- Insight into Tetramolecular DNA G-Quadruplexes Associated with ALS and FTLD: Cation Interactions and Formation of Higher-Ordered Structure.International journal of molecular sciences · 2023Article
- G-QINDER Tool: Bioinformatically Predicted Formation of Different Four-Stranded DNA Motifs from (GT)International journal of molecular sciences · 2023Article
- pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs.Journal of the American Chemical Society · 2023Article
- Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Non-G Base Tetrads.Molecules (Basel, Switzerland) · 2022Review
- Hidden Information Revealed Using the Orthogonal System of Nucleic Acids.International journal of molecular sciences · 2022Article
- Revealing structural peculiarities of homopurine GA repetition stuck by i-motif clip.Nucleic acids research · 2021Article
- Two coexisting pseudo-mirror heteromolecular telomeric G-quadruplexes in opposite loop progressions differentially recognized by a low equivalent of Thioflavin T.Nucleic acids research · 2021Article
- Rhodamine 6G-Ligand Influencing G-Quadruplex Stability and Topology.International journal of molecular sciences · 2021Article
- NMR structural study on the self-trimerization of d(GTTAGG) into a dynamic trimolecular G-quadruplex assembly preferentially in Na+ solution with a moderate K+ tolerance.Nucleic acids research · 2021Article
- Harnessing intrinsic fluorescence for typing of secondary structures of DNA.Nucleic acids research · 2020Article
- Chasing Particularities of Guanine- and Cytosine-Rich DNA Strands.Molecules (Basel, Switzerland) · 2020Article
- Intercalation of a Heterocyclic Ligand between Quartets in a G-Rich Tetrahelical Structure.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Probing G-quadruplex topologies and recognition concurrently in real time and 3D using a dual-app nucleoside probe.Nucleic acids research · 2019Article
- Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition.Molecular cell · 2018Article
- Expression of the human telomerase reverse transcriptase gene is modulated by quadruplex formation in its first exon due to DNA methylation.The Journal of biological chemistry · 2017Article
- Coexistence of two main folded G-quadruplexes within a single G-rich domain in the EGFR promoter.Nucleic acids research · 2017Article
- Tetrahelical structural family adopted by AGCGA-rich regulatory DNA regions.Nature communications · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA can form diverse higher-order structures, whose details are greatly dependent on nucleotide sequence. G-rich sequences containing four or more repeats of three guanines are expected to form G-quadruplexes. Here we show that DNA sequences with GGGAGCG repeats found in the regulatory region of the PLEKHG3 gene are capable of forming tetrahelical DNA structures that are distinct from G-quadruplexes. The d(GGGAGCGAGGGAGCG) sequence, VK1, forms a dimer. Two VK1 sequences connected by an adenine residue, VK2, fold into a monomer, which shares identical structural characteristics with the VK1 fold. Their four-stranded architectures are stabilized by four G-C, four G-A and six G-G base pairs. No G-quartets or Hoogsteen-type hydrogen-bonded guanine residues are present and the overall topology is conserved in the presence of Li(+), Na(+), K(+) and NH4(+) ions. Unique structural features include two edgewise loops on each side of the structure stabilized by three G-G base pairs in N1-carbonyl symmetric geometry.
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