SynthesisPediatric cardiology2015
Maternal reproductive history and the risk of congenital heart defects in offspring: a systematic review and meta-analysis.
Synthesis in Pediatric cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Assessment of evidence on reported non-genetic risk factors of congenital heart defects: the updated umbrella review.BMC pregnancy and childbirth · 2022Pooled it
- Environmental Risk Factors and Congenital Heart Disease: An Umbrella Review of 165 Systematic Reviews and Meta-Analyses With More Than 120 Million Participants.Frontiers in cardiovascular medicine · 2021Pooled it
- Risk-prediction nomogram for congenital heart disease in offspring of Chinese pregnant women.BMC pregnancy and childbirth · 2024Article
- Risk and protective factors related to having a child with congenital heart diseases (CHD): a case-control study in Iran.Frontiers in pediatrics · 2023Article
- Risk Assessment for Birth Defects in Offspring of Chinese Pregnant Women.International journal of environmental research and public health · 2022Article
- Maternal Risk Factors Triggering Congenital Heart Defects in Down Syndrome: A Case-Control Study.Pediatric reports · 2022Article
- Maternal sociodemographic characteristics, early pregnancy behaviours, and livebirth outcomes as congenital heart defects risk factors - Northern Ireland 2010-2014.BMC pregnancy and childbirth · 2021Article
- First-Trimester Maternal Folic Acid Supplementation Modifies the Effects of Risk Factors Exposures on Congenital Heart Disease in Offspring.Life (Basel, Switzerland) · 2021Article
- Parental occupational exposure and congenital heart diseases in a Hungarian case-control study.International archives of occupational and environmental health · 2021Article
- Pattern of congenital heart disease among Egyptian children: a 3-year retrospective study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2021Article
- Risk factors of congenital heart diseases: A hospital-based case-control study in Isfahan, Iran.ARYA atherosclerosis · 2020Article
- HAND1 Loss-of-Function Mutation Causes Tetralogy of Fallot.Pediatric cardiology · 2017Article
- Acute alcohol exposure during mouse gastrulation alters lipid metabolism in placental and heart development: Folate prevention.Birth defects research. Part A, Clinical and molecular teratology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have reported conflicting results on the association of congenital heart defect (CHD) risk in offspring with a maternal history of prior pregnancies and abortions, but no meta-analysis has been reported. We searched MEDLINE and EMBASE from their inception to April 14, 2014, for relevant studies that assessed the association between maternal reproductive history and CHD risk. Two authors independently assessed eligibility and extracted data. Fixed-effects or random-effects models were used to calculate the pooled odds ratios (ORs). Among 1,599 references, 17 case-control studies and one nested case-control study were included in this meta-analysis. The summary OR for the ever versus nulligravidity was 1.18 (95% CI 1.03-1.34). A dose-response analysis also indicated a positive effect of maternal gravidity on CHD risk, and the summary OR for each increment in number of pregnancies was 1.13 (95% CI 1.08-1.18). A history of abortion was associated with a 24% higher risk of CHD, OR = 1.24 (95% CI 1.11-1.38). When stratified by abortion category, CHD risk increased by 18 and 58% with a history of spontaneous abortion and induced abortion, respectively. The summary OR for each increment of one abortion was 1.28 (95% CI 1.18-1.40). In summary, this study provides evidence that increased maternal gravidity was positively associated with a risk of CHDs in offspring. Meanwhile, our results demonstrate a positive association of any history of abortion with an increased risk of CHDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.