ArticlePsychiatry research2015
5-HTTLPR × interpersonal stress interaction and nonsuicidal self-injury in general community sample of youth.
Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05765864 (Influences on and Prevention of Self-harm Behaviour Among the Most At-risk Adolescents), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influences on and Prevention of Self-harm Behaviour Among the Most At-risk Adolescents
Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Correlation of non-suicidal self-injury with SLC6A4 promoter DNA methylation in children and adolescents with bipolar depression.Frontiers in psychiatry · 2026Article
- Influences on and prevention of self-harm behavior among the most at-risk adolescents: study protocol for the SH-MARA prospective longitudinal cohort study.BMC psychiatry · 2025Article
- Longitudinal Relationship between Aggressive Behavior and Non-Suicidal Self-Injury among Adolescent Boys and Girls: The Mediating Role of Peer Victimization.Journal of youth and adolescence · 2025Article
- Molecular Pathways, Neural Circuits and Emerging Therapies for Self-Injurious Behaviour.International journal of molecular sciences · 2025Review
- Gender-Specific Trajectories of Non-Suicidal Self-Injury among Adolescents: Predictive Roles of Distal and Proximal Risk Factors.Journal of youth and adolescence · 2025Article
- The quest for a biological phenotype of adolescent non-suicidal self-injury: a machine-learning approach.Translational psychiatry · 2024Article
- Association of Non-Suicidal Self-Injury with Tryptophan Hydroxylase 2 Gene Polymorphism and Negative Life Events Among Adolescents with Depression in Northern China.Psychology research and behavior management · 2024Article
- Gender Differences of Antioxidant System and Thyroid Function in Depressed Adolescents with Non-Suicidal Self-Injury.Neuropsychiatric disease and treatment · 2024Article
- Risk factors, theoretical models, and biological mechanisms of nonsuicidal self-injury: a brief review.Interdisciplinary nursing research · 2023Review
- The relationship between family cohesion and adaptability and non-suicidal self-injury behavior in ethnic minority adolescents: a moderating mediation model.Frontiers in psychology · 2023Article
- A cross-sectional study of non-suicidal self-injury in a Chinese adolescent inpatient cohort.Frontiers in psychiatry · 2023Article
- A nonhuman primate model of human non-suicidal self-injury: serotonin-transporter genotype-mediated typologies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Association Between Non-Suicidal Self-Injury and Gut Microbial Characteristics in Chinese Adolescent.Neuropsychiatric disease and treatment · 2022Article
- Harsh parenting and non-suicidal self-injury in adolescence: the mediating effect of depressive symptoms and the moderating effect of the COMT Val158Met polymorphism.Child and adolescent psychiatry and mental health · 2021Article
- Parental Bonding and Children's Psychopathology: A Transgenerational View Point.Children (Basel, Switzerland) · 2021Article
- Advancing a temporal framework for understanding the biology of nonsuicidal self- injury: An expert review.Neuroscience and biobehavioral reviews · 2021Review
- The Interplay of Chronic Interpersonal Stress and Rumination on Nonsuicidal Self-Injury in Youth.Research on child and adolescent psychopathology · 2021Article
- Salivary beta-endorphin in nonsuicidal self-injury: an ambulatory assessment study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- The Effects of Childhood Maltreatment on Non-Suicidal Self-Injury in Male Adolescents: The Moderating Roles of the Monoamine Oxidase A (MAOA) Gene and the Catechol-O-Methyltransferase (COMT) Gene.International journal of environmental research and public health · 2021Article
- A Rhesus Monkey Model of Non-suicidal Self-Injury.Frontiers in behavioral neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
No research with youth has investigated whether measured genetic risk interacts with stressful environment (G⁎E) to explain engagement in non-suicidal self-injury (NSSI). Two independent samples of youth were used to test the a priori hypothesis that the Transporter-Linked Polymorphic Region (5-HTTLPR) would interact with chronic interpersonal stress to predict NSSI. We tested this hypothesis with children and adolescents from United States public schools in two independent samples (N׳s=300 and 271) using identical procedures and methods. They were interviewed in person with the Self-Injurious Thoughts and Behaviors Interview to assess NSSI engagement and with the UCLA Chronic Stress Interview to assess interpersonal stress. Buccal cells were collected for genotyping of 5-HTTLPR. For both samples, ANOVAs revealed the hypothesized G*E. Specifically, short carriers who experienced severe interpersonal stress exhibited the highest level of NSSI engagement. Replicated across two independent samples, results provide the first demonstration that youth at high genetic susceptibility (5-HTTLPR) and high environmental exposure (chronic interpersonal stress) are at heightened risk for NSSI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.