Evidence map›Paper›PMID 25500329›Full record

Trial reportGastrointestinal endoscopy2015

Volatile organic compounds in bile for early diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis: a pilot study.

Udayakumar Navaneethan, Mansour A Parsi, Vennisvasanth Lourdusamy, Amit Bhatt, Norma G Gutierrez, David Grove, Madhusudhan R Sanaka, Jeffrey P Hammel, Tyler Stevens, John J Vargo and 1 more

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gastrointestinal endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01565460 (Bile and Bile Duct/Pancreatic Duct Brushings Database for Patients With Pancreato-biliary Stricture), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01565460 completednot on this map

Bile and Bile Duct/Pancreatic Duct Brushings Database for Patients With Pancreato-biliary Stricture

TypeobservationalSponsorThe Cleveland ClinicRan2012 to 2016Enrolled200ConditionsPancreatic Duct Strictures, Biliary Duct StricturesArmsSample Collection
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Udayakumar NavaneethanDepartment of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Mansour A ParsiDepartment of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Vennisvasanth LourdusamyDepartment of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Amit BhattDepartment of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Norma G GutierrezDepartment of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.
David GrovePathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Madhusudhan R SanakaDepartment of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Jeffrey P HammelDepartment of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Tyler StevensDepartment of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.
John J VargoDepartment of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Raed A DweikPathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI REIZES, OFER · 2011 to 2020
$26.8M
Tissue Processing and Cell Culture COreP01HL081064 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ARONICA, MARK A · 2006 to 2019
$17.8M
VERSICAN PROTEOLYSIS AND REGULATION OF VASCULAR SMOOTH MUSCLEP01HL107147 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI LAUER, MARK E · 2011 to 2017
$16.1M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Laser spectroscopic instrumentation for isotopic sensing of biogenic Nitric OxideR21RR026231 · NCRR · PRINCETON UNIVERSITY · PI WYSOCKI, GERARD · 2010 to 2011
$380k
NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1TR 000439-06NCRR NIH HHS R21 RR026231NCRR NIH HHS RR026231NHLBI NIH HHS HL081064NHLBI NIH HHS HL103453NHLBI NIH HHS HL107147NHLBI NIH HHS HL109250NHLBI NIH HHS P01 HL081064NHLBI NIH HHS P01 HL103453NHLBI NIH HHS P01 HL107147NHLBI NIH HHS U10 HL109250
6 · The paper itself

Abstract

backgroundThe diagnosis of cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC) is particularly difficult. The role of volatile organic compounds (VOCs) for diagnosis of CCA in patients with PSC is not known.

objectiveOur aim was to identify potential VOCs in the headspaces (gas above the sample) in bile that may predict CCA in patients with PSC.

designProspective cross-sectional study.

settingReferral center. PATIENTS: A total of 32 patients undergoing ERCP for PSC and for CCA complicating PSC.

interventionsERCP, bile aspiration. MAIN OUTCOME MEASUREMENTS: Selected ion flow tube mass spectrometry was used to analyze the concentration of 22 prevalent VOCs in bile samples. Logistic regression analysis was performed to build a predictive model for diagnosis of CCA.

resultsLevels of several compounds (ethanol, acrylonitrile, acetonitrile, acetaldehyde, benzene, carbon disulfide, dimethyl sulfide, 2-propranolol) were significantly different in patients with CCA complicating PSC compared with those having PSC (P < .05). By using receiver operating characteristic curve analysis, we developed a model for the diagnosis of CCA adjusted for age and sex based on VOC levels of acrylonitrile, 3-methyl hexane, and benzene. The model (2.3239*log [acrylonitrile] + 0.9871*log [3-methyl hexane] + 0.8448*log [benzene]) < -0.12 identified the patients with CCA (area under the curve [AUC] = 0.89), with 90.5% sensitivity and 72.7% specificity (P = .02). LIMITATIONS: Sample size.

conclusionThe measurement of VOCs in biliary fluid may be useful to diagnose CCA in patients with PSC. A larger study with a longitudinal study design is required to confirm our pilot observations to diagnose CCA early in patients with PSC. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT01565460.).

Indexed as

Early Detection of CancerAcrylonitrileArea Under CurveBenzeneBileBile Duct NeoplasmsBiomarkers, TumorCholangiocarcinomaCholangitis, SclerosingCross-Sectional StudiesFemaleHexanesHumansMaleMass SpectrometryPilot Projects3-methylhexaneAcrylonitrileBenzeneBiomarkers, TumorHexanesVolatile Organic Compounds

Identifiers

PMID25500329
PMCPMC4375033
OpenAlexW2007074761

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.