ArticleExperimental neurology2015
Spreading depression transiently disrupts myelin via interferon-gamma signaling.
Article in Experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Plasma SuPAR and therapeutic response to erenumab in migraine: a REFORM study.The journal of headache and pain · 2025Trial
- Targeting glial-orchestrated neuroinflammation in migraine pathophysiology.The journal of headache and pain · 2026Review
- The link between spreading depolarization and innate immunity in the central nervous system.The journal of headache and pain · 2025Review
- Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective.Frontiers in nutrition · 2024Article
- Glia Signaling and Brain Microenvironment in Migraine.Molecular neurobiology · 2023Review
- Selected Biomarkers of Depression: What Are the Effects of Cytokines and Inflammation?International journal of molecular sciences · 2022Review
- Unique aspects of IFN-γ/STAT1 signaling in neurons.Immunological reviews · 2022Review
- IFNγ-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytes.PloS one · 2021Article
- Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic.Journal of cellular immunology · 2021Article
- Migrainous Infarction and Cortical Spreading Depression.Discoveries (Craiova, Romania) · 2020Review
- The role of the immune system and the biomarker CD3 + CD4 + CD45RA-CD62L- in the pathophysiology of migraine.Scientific reports · 2020Article
- Effect of Sox10 on remyelination of the hippocampus in cuprizone-induced demyelinated mice.Brain and behavior · 2020Article
- Non-invasively triggered spreading depolarizations induce a rapid pro-inflammatory response in cerebral cortex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Spreading depression as a preclinical model of migraine.The journal of headache and pain · 2019Review
- IFNγ-Stimulated Dendritic Cell Exosomes for Treatment of Migraine Modeled Using Spreading Depression.Frontiers in neuroscience · 2019Article
- Taurine/Pilocarpine Interaction in the Malnourished Rat Brain: A Behavioral, Electrophysiological, and Immunohistochemical Analysis.Frontiers in neuroscience · 2019Article
- Sub-Convulsing Dose Administration of Pilocarpine Reduces Glycemia, Increases Anxiety-Like Behavior and Decelerates Cortical Spreading Depression in Rats Suckled on Various Litter Sizes.Frontiers in neuroscience · 2018Article
- Intranasally administered IGF-1 inhibits spreading depression in vivo.Brain research · 2017Article
- Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine.Molecular neurobiology · 2017Article
- Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation.Cellular and molecular neurobiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Multiple sclerosis and migraine with aura are clinically correlated and both show imaging changes suggestive of myelin disruption. Furthermore, cortical myelin loss in the cuprizone animal model of multiple sclerosis enhances susceptibility to spreading depression, the likely underlying cause of migraine with aura. Since multiple sclerosis pathology involves inflammatory T cell lymphocyte production of interferon-gamma and a resulting increase in oxidative stress, we tested the hypothesis that spreading depression disrupts myelin through similar signaling pathways. Rat hippocampal slice cultures were initially used to explore myelin loss in spreading depression, since they contain T cells, and allow for controlled tissue microenvironment. These experiments were then translated to the in vivo condition in neocortex. Spreading depression in slice cultures induced significant loss of myelin integrity and myelin basic protein one day later, with gradual recovery by seven days. Myelin basic protein loss was abrogated by T cell depletion, neutralization of interferon-gamma, and pharmacological inhibition of neutral sphingomyelinase-2. Conversely, one day after exposure to interferon-gamma, significant reductions in spreading depression threshold, increases in oxidative stress, and reduced levels of glutathione, an endogenous neutral sphingomyelinase-2 inhibitor, emerged. Similarly, spreading depression triggered significant T cell accumulation, sphingomyelinase activation, increased oxidative stress, and reduction of gray and white matter myelin in vivo. Myelin disruption is involved in spreading depression, thereby providing pathophysiological links between multiple sclerosis and migraine with aura. Myelin disruption may promote spreading depression by enhancing aberrant excitability. Thus, preservation of myelin integrity may provide novel therapeutic targets for migraine with aura.
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