Evidence map›Paper›PMID 25500076›Full record

ArticleTranslational oncology2014

Advanced 3D-Sonographic Imaging as a Precise Technique to Evaluate Tumor Volume.

R Pflanzer, M Hofmann, A Shelke, A Habib, W Derwich, T Schmitz-Rixen, A Bernd, R Kaufmann, J Bereiter-Hahn

Abstract read
In one paragraph

Article in Translational oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Bivalent EGFR-Targeting DARPin-MMAE Conjugates.International journal of molecular sciences · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

R PflanzerDept. of Dermatology, Venerology and Allergology, Goethe University Frankfurt, 60590 Frankfurt/Main, Germany.
M HofmannDept. of Dermatology, Venerology and Allergology, Goethe University Frankfurt, 60590 Frankfurt/Main, Germany. Electronic address: Matthias.Hofmann@em.uni-frankfurt.de.
A ShelkeInstitute for Cell Biology and Neurosciences, Goethe University, 60439 Frankfurt/Main, Germany.
A HabibInstitute for Cell Biology and Neurosciences, Goethe University, 60439 Frankfurt/Main, Germany.
W DerwichDept. of Vascular and Endovascular Surgery, Goethe University Frankfurt, 60590 Frankfurt/Main, Germany.
T Schmitz-RixenDept. of Vascular and Endovascular Surgery, Goethe University Frankfurt, 60590 Frankfurt/Main, Germany.
A BerndDept. of Dermatology, Venerology and Allergology, Goethe University Frankfurt, 60590 Frankfurt/Main, Germany.
R KaufmannDept. of Dermatology, Venerology and Allergology, Goethe University Frankfurt, 60590 Frankfurt/Main, Germany.
J Bereiter-HahnInstitute for Cell Biology and Neurosciences, Goethe University, 60439 Frankfurt/Main, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Determination of tumor volume in subcutaneously inoculated xenograft models is a standard procedure for clinical and preclinical evaluation of tumor response to treatment. Practitioners frequently use a hands-on caliper method in conjunction with a simplified formula to assess tumor volume. Non-invasive and more precise techniques as investigation by MR or (μ)CT exist but come with various adverse effects in terms of radiation, complex setup or elevated cost of investigations. Therefore, we propose an advanced three-dimensional sonographic imaging technique to determine small tumor volumes in xenografts with high precision and minimized observer variability. We present a study on xenograft carcinoma tumors from which volumes and shapes were calculated with the standard caliper method as well as with a clinically available three-dimensional ultrasound scanner and subsequent processing software. Statistical analysis reveals the suitability of this non-invasive approach for the purpose of a quick and precise calculation of tumor volume in small rodents.

Identifiers

PMID25500076
PMCPMC4311038

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.