ArticleVision research2015
Modeling the response of ON and OFF retinal bipolar cells during electric stimulation.
Article in Vision research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Inhibitory Circuits Can Restore OFF Pathway Responses in Retinal Prostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Maximizing the fidelity of a photovoltaic subretinal prosthesis for human patients.Journal of neural engineering · 2026Article
- Development of digital hardware for a spiking image recognition network employing a novel burst-based reinforcement learning approach.Scientific reports · 2025Article
- Amorphous silicon resistors enable smaller pixels in photovoltaic retinal prosthesis.Journal of neural engineering · 2025Article
- Restoration of Sight with Electronic Retinal Prostheses.Annual review of vision science · 2025Review
- Amorphous silicon resistors enable smaller pixels in photovoltaic retinal prosthesis.bioRxiv : the preprint server for biology · 2025Article
- An accurate and fast learning approach in the biologically spiking neural network.Scientific reports · 2025Article
- A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina.Nature communications · 2025Article
- Spatially Localized Visual Perception Estimation by Means of Prosthetic Vision Simulation.Journal of imaging · 2024Article
- Article
- Digital design of a spatial-pow-STDP learning block with high accuracy utilizing pow CORDIC for large-scale image classifier spatiotemporal SNN.Scientific reports · 2024Article
- Artificial Vision: The High-Frequency Electrical Stimulation of the Blind Mouse Retina Decay Spike Generation and Electrogenically Clamped Intracellular CaBioengineering (Basel, Switzerland) · 2023Article
- Electronic Retinal Prostheses.Cold Spring Harbor perspectives in medicine · 2023Review
- Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- Photovoltaic implant simulator reveals resolution limits in subretinal prosthesis.Journal of neural engineering · 2022Article
- Pixel size limit of the PRIMA implants: from humans to rodents and back.Journal of neural engineering · 2022Article
- Reply to: Questions about the role of P3HT nanoparticles in retinal stimulation.Nature nanotechnology · 2021Article
- Questions about the role of P3HT nanoparticles in retinal stimulation.Nature nanotechnology · 2021Article
- A Computational Model Simulates Light-Evoked Responses in the Retinal Cone Pathway.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Retinal implants allowing blind people suffering from diseases like retinitis pigmentosa and macular degeneration to regain rudimentary vision are struggling with several obstacles. One of the main problems during external electric stimulation is the co-activation of the ON and OFF pathways which results in mutual impairment. In this study the response of ON and OFF cone retinal bipolar cells during extracellular electric stimulation from the subretinal space was examined. To gain deeper insight into the behavior of these cells sustained L-type and transient T-type calcium channels were integrated in the synaptic terminals of reconstructed 3D morphologies of ON and OFF cone bipolar cells. Intracellular calcium concentration in the synaptic regions of the model neurons was investigated as well since calcium influx is a crucial parameter for cell-to-cell activity between bipolar cells and retinal ganglion cells. It was shown that monophasic stimulation results in significant different calcium concentrations in the synaptic terminals of ON and OFF bipolar cells. Intracellular calcium increased to values up to fourfold higher in the OFF bipolar model neuron in comparison to the ON bipolar cell. Furthermore, geometric properties strongly influence the activation of bipolar cells. Monophasic, biphasic, single and repetitive pulses with similar lengths, amplitudes and polarities were applied to the two model neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.