ArticleDiagnostic pathology2014
p16(INK4a) expression in retinoblastoma: a marker of differentiation grade.
Article in Diagnostic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Longitudinal analysis of retinal cell state transitions in RB1-deficient retinal organoids reveals the nascent cone precursors are the earliest cell-origin of human retinoblastoma.Cell death & disease · 2026Article
- Tumor heterogeneity in retinoblastoma: a literature review.Cancer metastasis reviews · 2025Review
- Gene expression study in retinoblastoma patients with different anaplasias and lateralities.Scientific reports · 2025Article
- Retinocytoma: understanding pathogenesis, diagnosis, and treatment approaches.International journal of retina and vitreous · 2025Review
- Therapy for Hormone Receptor-Positive, Human Epidermal Growth Receptor 2-Negative Metastatic Breast Cancer Following Treatment Progression via CDK4/6 Inhibitors: A Literature Review.Breast cancer (Dove Medical Press) · 2024Review
- Advances in Therapy for Hormone Receptor (HR)-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Advanced Breast Cancer Patients Who Have Experienced Progression After Treatment with CDK4/6 Inhibitors.OncoTargets and therapy · 2021Review
- Discovery of a transcriptomic core of genes shared in 8 primary retinoblastoma with a novel detection score analysis.Journal of cancer research and clinical oncology · 2020Article
- Current Therapeutic Progress of CDK4/6 Inhibitors in Breast Cancer.Cancer management and research · 2020Review
- Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review.International journal of cancer · 2019Review
- Review
- [Retinoblastoma and retinocytoma (retinoma)].Der Pathologe · 2017Review
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7 authors.
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Abstract
backgroundThe tumor suppressor protein p16(INK4a) has been extensively studied in many tumors with very different results, ranging from its loss to its clear overexpression, which may be associated with degree of tumor differentiation and prognosis. However, its expression remains unclear in human retinoblastoma (RB), a common malignant tumor of retina in childhood. The aim of this study was to explore the expression pattern of p16(INK4a) in RB, and the correlation between p16(INK4a) expression and histopathological features of RB.
methodsSixty-five cases of RB were retrospectively analyzed. Paraffin-embedded blocks were retrieved from the archives of ocular pathology department at Zhongshan Ophthalmic Center of Sun Yat-sen University, China. Serial sections were cut and subjected to hematoxylin and eosin staining. Immunohistochemical staining was further done with antibodies p16(INK4a), CRX and Ki67. The correlation of p16 (INK4a) expression with CRX and Ki67 and clinicopathological features of RB were analyzed.
resultsRB tumor histologically consists of various differentiation components including undifferentiated (UD) cells, Homer-Wright rosettes (HWR) or Flexner-Winterstein rosettes (FWR) and fleurettes characteristic of photoreceptor differentiation or Retinocytoma (RC). p16(INK4a) expression was negative in both fleurette region and the residual retinal tissue adjacent to the tumor, weakly to moderately positive in FWR, strongly positive in both HWR and UD region. However, CRX had the reverse expression patterns in comparison with p16(INK4a). It was strongly positive in photoreceptor cells within the residual retina and fleurettes, but weakly to moderately positive in UD area. Together with Ki67 staining, high p16(INK4a) expression was associated with poor histological differentiation of RB tumors, which had higher risk features with the optic nerve invasion and uveal invasion.
conclusionsp16(INK4a) expression increased with the decreasing level of cell differentiation of RBs. RB tumors extensively expressing p16(INK4a) tended to have higher risk features with poor prognosis. This study suggested that p16(INK4a) would be a valuable molecular marker of RB to distinguish its histological phenotypes and to serve as a predictor of its prognosis. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_180.
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