Evidence map›Paper›PMID 25499068›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2015

Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report.

Amy M Linabery, Wenchao Li, Michelle A Roesler, Logan G Spector, Alan S Gamis, Andrew F Olshan, Nyla A Heerema, Julie A Ross

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Amy M LinaberyDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota. University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota. linabery@umn.edu.
Wenchao LiDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Michelle A RoeslerUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota.
Logan G SpectorDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota. University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota.
Alan S GamisDivision of Hematology-Oncology, The Children's Mercy Hospital, Kansas City, Missouri.
Andrew F OlshanDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.
Nyla A HeeremaDepartment of Pathology, The Ohio State University, Columbus, Ohio.
Julie A RossDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota. University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota.
University of Minnesota · USUniversity of North Carolina at Chapel Hill · US

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
CHILDRENS CANCER STUDY GROUP CHAIRMAN'S GRANTU10CA013539 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI REAMAN, GREGORY H · 1985 to 2002
$43.1M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
EPIDEMIOLOGY OF DOWN SYNDROME--LEUKEMIA &DOWN SYNDROMER01CA075169 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROSS, JULIE ANN · 1997 to 2001
$883k
Established Investigator Award in Pediatric Cancer EpidemiologyK05CA157439 · NCI · UNIVERSITY OF MINNESOTA · PI ROSS, JULIE ANN · 2011 to 2015
$695k
NCI NIH HHS K05 CA157439NCI NIH HHS R01 CA075169NCI NIH HHS R01 CA75169NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA13539NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA98543NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES10126
6 · The paper itself

Abstract

backgroundChildren with Down syndrome have unique immune profiles and increased leukemia susceptibility.

methodsMothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.

resultsNo associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis. CONCLUSIONS AND IMPACT: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.

Indexed as

AdolescentChildChild, PreschoolDiabetes MellitusDown SyndromeFemaleHumansImmune System DiseasesInfantInfant, NewbornLeukemia, Myeloid, AcuteLogistic ModelsMalePrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsYoung Adult

Identifiers

PMID25499068
PMCPMC4323733
OpenAlexW2110810293

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.