ArticleMolecular and cellular endocrinology2015
Daily successive changes in reproductive gene expression and neuronal activation in the brains of pubertal female mice.
Article in Molecular and cellular endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 66 citations in OpenAlex.
- Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females.Endocrinology · 2026Article
- Neuronal plasticity at puberty in mouse hypothalamicProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptomic profiling of hypothalamic development in female rats.Molecular and cellular endocrinology · 2025Article
- Activity of arcuate kisspeptin/neurokinin B neurons and the melanocortin system during pubertal development in female sheep†.Biology of reproduction · 2025Article
- Sodium benzoate exposure from juvenile to peripubertal period disrupts HPG-axis in both male and female rats.Toxicological research · 2025Article
- RFRP Neurons Are Required for Acute Stress-induced Suppression of the Estrogen-stimulated LH Surge in Female Mice.Endocrinology · 2025Article
- Shared Pathophysiological Mechanisms and Genetic Factors in Early Menarche and Polycystic Ovary Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Complement receptorBrain communications · 2025Article
- Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Early life adversity accelerates hypothalamic drive of pubertal timing in female rats with associated enhanced acoustic startle.Hormones and behavior · 2024Article
- The Role of RFRP Neurons in the Allostatic Control of Reproductive Function.International journal of molecular sciences · 2023Review
- Variation in Hypothalamic GnIH Expression and Its Association withAnimals : an open access journal from MDPI · 2022Article
- Conditional Deletion of KOR (Oprk1) in Kisspeptin Cells Does Not Alter LH Pulses, Puberty, or Fertility in Mice.Endocrinology · 2022Article
- Developmental sex differences in the peri-pubertal pattern of hypothalamic reproductive gene expression, including Kiss1 and Tac2, may contribute to sex differences in puberty onset.Molecular and cellular endocrinology · 2022Article
- Serum kisspeptin levels mainly depend on ovarian expression ofFrontiers in physiology · 2022Article
- Neuroendocrine mechanisms underlying estrogen positive feedback and the LH surge.Frontiers in neuroscience · 2022Review
- Maternal aromatase inhibition via letrozole altered RFamide-related peptide-3 and gonadotropin-releasing hormone expression in pubertal female rats.Iranian journal of basic medical sciences · 2022Article
- Progesterone Receptors in AVPV Kisspeptin Neurons Are Sufficient for Positive Feedback Induction of the LH Surge.Endocrinology · 2021Article
- Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep.Biology · 2021Article
- Estrogen Regulation of the Molecular Phenotype and Active Translatome of AVPV Kisspeptin Neurons.Endocrinology · 2021Article
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2 authors at 1 institution in 1 country.
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Abstract
Puberty is governed by the secretion of gonadotropin releasing hormone (GnRH), but the roles and identities of upstream neuropeptides that control and time puberty remain poorly understood. Indeed, how various reproductive neural gene systems change before and during puberty, and in relation to one another, is not well-characterized. We detailed the daily pubertal profile (from postnatal day [PND] 15 to PND 30) of neural Kiss1 (encoding kisspeptin), Kiss1r (kisspeptin receptor), Tac2 (neurokinin B), and Rfrp (RFRP-3, mammalian GnIH) gene expression and day-to-day c-fos induction in each of these cell types in developing female mice. Kiss1 expression in the AVPV/PeN increased substantially over the pubertal transition, reaching adult levels around vaginal opening (PND 27.5), a pubertal marker. However, AVPV/PeN Kiss1 neurons were not highly activated, as measured by c-fos co-expression, at any pubertal age. In the ARC, Kiss1 and Tac2 cell numbers showed moderate increases across the pubertal period, and neuronal activation of Tac2/Kiss1 cells was moderately elevated at all pubertal ages. Additionally, Kiss1r expression specifically in GnRH neurons was already maximal by PND 15 and did not change with puberty. Conversely, both Rfrp expression and Rfrp/c-fos co-expression in the DMN decreased markedly in the early pre-pubertal stage. This robust decrease of the inhibitory RFRP-3 population may diminish inhibition of GnRH neurons during early puberty. Collectively, our data identify the precise timing of important developmental changes - and in some cases, lack thereof - in gene expression and neuronal activation of key reproductive neuropeptides during puberty, with several changes occurring well before vaginal opening.
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