Evidence map›Paper›PMID 25498591›Full record

ArticleOsteoarthritis and cartilage2015

Altered regional loading patterns on articular cartilage following meniscectomy are not fully restored by autograft meniscal transplantation.

H Wang, T Chen, A O Gee, I D Hutchinson, K Stoner, R F Warren, S A Rodeo, S A Maher

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Impediments to Meniscal Repair: Factors at Play Beyond Vascularity.Frontiers in bioengineering and biotechnology · 2022
    Article
  3. Article
  4. Review
  5. Article
  6. Fatigue life of bovine meniscus under longitudinal and transverse tensile loading.Journal of the mechanical behavior of biomedical materials · 2017
    Article
  7. Meniscus tear surgery and meniscus replacement.Muscles, ligaments and tendons journal
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

H WangDepartment of Biomechanics, Hospital for Special Surgery, 535 E 70st St., New York, NY 10021, USA.
T ChenDepartment of Biomechanics, Hospital for Special Surgery, 535 E 70st St., New York, NY 10021, USA.
A O GeeSports Medicine and Shoulder Service, Hospital for Special Surgery, 535 E 70st St., New York, NY 10021, USA; Orthopaedics and Sports Medicine, University of Washington School of Medicine, 535 E 70st St., New York, NY 10021, USA.
I D HutchinsonDepartment of Biomechanics, Hospital for Special Surgery, 535 E 70st St., New York, NY 10021, USA; Orthopaedic Surgery, Wake Forest School of Medicine, 535 E 70st St., New York, NY 10021, USA.
K StonerDepartment of Biomechanics, Hospital for Special Surgery, 535 E 70st St., New York, NY 10021, USA; Department of Biomedical Engineering, University of Iowa, 535 E 70st St., New York, NY 10021, USA.
R F WarrenSports Medicine and Shoulder Service, Hospital for Special Surgery, 535 E 70st St., New York, NY 10021, USA.
S A RodeoSports Medicine and Shoulder Service, Hospital for Special Surgery, 535 E 70st St., New York, NY 10021, USA.
S A MaherDepartment of Biomechanics, Hospital for Special Surgery, 535 E 70st St., New York, NY 10021, USA. Electronic address: mahers@hss.edu.
Hospital for Special Surgery · USUniversity of Iowa · US

Funding

Clinical and Translational Science CenterKL2TR000458 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$2.1M
Designing a meniscal substitute through an integrated experimental computationalR01AR057343 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI MAHER, SUZANNE A. · 2010 to 2013
$1.5M
NCATS NIH HHS KL2 TR000458NIAMS NIH HHS R01 AR057343
6 · The paper itself

Abstract

objectiveTo quantify the changes in regional dynamic loading patterns on tibial articular cartilage during simulated walking following medial meniscectomy and meniscal transplantation.

methodsSeven fresh frozen human cadaveric knees were tested under multidirectional loads mimicking the activity of walking, while the contact stresses on the tibial plateau were synchronously recorded using an electronic sensor. Each knee was tested for three conditions: intact meniscus, medial meniscectomy, and meniscal transplantation. The loading profiles at different locations were assessed and common loading patterns were identified at different sites of the tibial plateau using an established numerical algorithm.

resultsThree regional patterns were found on the tibial plateau of intact knees. Following medial meniscectomy, the area of the first pattern which was located at the posterior aspect of the medial plateau was significantly reduced, while the magnitude of peak load was significantly increased by 120%. The second pattern which was located at the central-posterior aspects of the lateral plateau shifted anteriorly and laterally without changing its magnitude. The third pattern in the cartilage-to-cartilage contact region of the medial plateau was absent following meniscectomy. Meniscal transplantation largely restored the first pattern, but it did not restore the other two patterns.

conclusionThere are site-dependent changes in regional loading patterns on both the medial and lateral tibial plateau following medial meniscectomy. Even when a meniscal autograft is used where the geometry and material properties are kept constant, the only region in which the loading pattern is restored is at posterior aspect of the medial plateau.

Indexed as

Biomechanical PhenomenaCadaverCartilage, ArticularHumansKnee JointMenisci, TibialRetrospective StudiesTibiaTransplantation, AutologousWeight-BearingCadaveric modelContact mechanicsKnee simulatorPressure sensorTekscan

Identifiers

PMID25498591
PMCPMC4339622
OpenAlexW2035099901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.