Evidence map›Paper›PMID 25498451›Full record

ArticleBlood2014

Hypoxic exosomes promote angiogenesis.

Guo-Chang Fan

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 47 citations in OpenAlex.

  1. New insights into extracellular vesicles in metastatic cancer: From mechanisms to diagnostics and targeted therapies.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  2. Review
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  4. Review
  5. Review
  6. Article
  7. Review
  8. Promising Scaffold-Free Approaches in Translational Dentistry.International journal of environmental research and public health · 2020
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Stem Cell Extracellular Vesicles in Skin Repair.Bioengineering (Basel, Switzerland) · 2018
    Review
  15. Article
  16. Review
  17. Review
  18. Tissue engineering. Part A · 2017
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Guo-Chang FanUNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE.ORCID http://orcid.org/0000-0002-0439-8277
University of Cincinnati Medical Center · US

Funding

Roles of Hsp20-Exosomes in Myocardial AngiogenesisR01HL087861 · NHLBI · UNIVERSITY OF CINCINNATI · PI FAN, GUO-CHANG · 2007 to 2017
$4.2M
Duplex miR-223 and Exosomes in SepsisR01GM112930 · NIGMS · UNIVERSITY OF CINCINNATI · PI FAN, GUO-CHANG · 2015 to 2018
$1.2M
NHLBI NIH HHS R01 HL087861NIGMS NIH HHS R01 GM112930
6 · The paper itself

Abstract

In this issue of Blood, Umezu et al identified that exosomal miR-135b plays a critical role in mediating multiple myeloma (MM) cell-to-endothelial cell communication under chronic hypoxia.

Indexed as

ExosomesHumansMicroRNAsMixed Function OxygenasesNeovascularization, PathologicRepressor ProteinsHIF1AN protein, humanMicroRNAsMIRN135 microRNA, humanMixed Function OxygenasesRepressor Proteins

Identifiers

PMID25498451
OpenAlexW1969525151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.