ReviewCellular immunology2015
Sex-specific immune modulation of primary hypertension.
Review in Cellular immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Defining the effects of age and gender on immune response and outcomes to melanoma vaccination: a retrospective analysis of a single-institution clinical trials' experience.Cancer immunology, immunotherapy : CII · 2015Trial
- Revisiting sex as a biological variable in hypertension research.The Journal of clinical investigation · 2024Review
- Mechanisms and consequences of sex differences in immune responses.Nature reviews. Nephrology · 2024Review
- Male and female high-fat diet-fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences.American journal of physiology. Heart and circulatory physiology · 2021Article
- Central Ang II (Angiotensin II)-Mediated Sympathoexcitation: Role for HIF-1α (Hypoxia-Inducible Factor-1α) Facilitated Glutamatergic Tone in the Paraventricular Nucleus of the Hypothalamus.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease.Clinical science (London, England : 1979) · 2020Review
- Sex differences in stroke co-morbidities.Experimental neurology · 2020Review
- Resilience factors, race/ethnicity and sleep disturbance among diverse older females with hypertension.Journal of affective disorders · 2020Article
- DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.Circulation · 2020Article
- Renal T cell infiltration occurs despite attenuation of development of hypertension with hydralazine in Envigo's female Dahl rat maintained on a low-NaAmerican journal of physiology. Renal physiology · 2019Article
- Immune mechanisms of hypertension.Nature reviews. Immunology · 2019Review
- Adaptive Immunity in Hypertension.Current hypertension reports · 2019Review
- Renal nerves and leukocyte infiltration in the kidney during salt-sensitive hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Genetic disruption ofAmerican journal of physiology. Renal physiology · 2019Article
- β‑estradiol alleviates hypertension‑ and concanavalin A‑mediated inflammatory responses via modulation of connexins in peripheral blood lymphocytes.Molecular medicine reports · 2019Article
- T Cells and Hypertension: Solved and Unsolved Mysteries Regarding the Female Rat.Physiology (Bethesda, Md.) · 2018Review
- Kidneys and women's health: key challenges and considerations.Nature reviews. Nephrology · 2018Article
- Role of Kidneys in Sex Differences in Angiotensin II-Induced Hypertension.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Cross-sex transplantation alters gene expression and enhances inflammatory response in the transplanted kidneys.American journal of physiology. Renal physiology · 2017Article
- Sex differences in stroke across the lifespan: The role of T lymphocytes.Neurochemistry international · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
It is well known that the onset of essential hypertension occurs earlier in men than women. Numerous studies have shown sex differences in the vasculature, kidney and sympathetic nervous system contribute to this sex difference in the development of hypertension. The immune system also contributes to the development of hypertension; however, sex differences in immune system modulation of blood pressure (BP) and the development of hypertension has only recently begun to be explored. Here we review findings on the effect of one's sex on the immune system and specifically how these effects impact BP and the development of primary hypertension. We also propose a hypothesis for why mechanisms underlying inflammation-induced hypertension are sex-specific. These studies underscore the value of and need for studying both sexes in the basic science exploration of the pathophysiology of hypertension as well as other diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.