ArticleMolecular cell2015
Pathogenicity island-directed transfer of unlinked chromosomal virulence genes.
Article in Molecular cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
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- Virion content unpacked by long-read sequencing: stress-induced changes in transmitted staphylococcal mobilome due to phage-satellite interactions.Nucleic acids research · 2025Article
- Genetics, ecology and evolution of phage satellites.Nature reviews. Microbiology · 2025Review
- Molecular piracy in deep-sea hydrothermal vent: phage-plasmid interactions revealed by phage-FISH inApplied and environmental microbiology · 2025Article
- Analysis of co-occurrence of type II toxin-antitoxin systems and antibiotic resistance determinants inmSystems · 2025Article
- A phage satellite manipulates the viral DNA packaging motor to inhibit phage and promote satellite spread.Nucleic acids research · 2024Article
- A phage satellite manipulates the viral DNA packaging motor to inhibit phage and promote satellite spread.bioRxiv : the preprint server for biology · 2024Article
- Marine viral particles reveal an expansive repertoire of phage-parasitizing mobile elements.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition.PLoS pathogens · 2022Article
- Global Transcriptomic Analysis of Bacteriophage-Host Interactions between a Kayvirus Therapeutic Phage and Staphylococcus aureus.Microbiology spectrum · 2022Article
- Insights into Gene Transcriptional Regulation ofViruses · 2022Article
- Phage-inducible chromosomal islands promote genetic variability by blocking phage reproduction and protecting transductants from phage lysis.PLoS genetics · 2022Article
- Phage-mediated horizontal gene transfer and its implications for the human gut microbiome.Gastroenterology report · 2022Article
- The phages of staphylococci: critical catalysts in health and disease.Trends in microbiology · 2021Review
- Phage satellites and their emerging applications in biotechnology.FEMS microbiology reviews · 2021Review
- Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements.Nature communications · 2021Article
- Staphylococcal phages and pathogenicity islands drive plasmid evolution.Nature communications · 2021Article
- Inferring multilayer interactome networks shaping phenotypic plasticity and evolution.Nature communications · 2021Article
- Staphylococcus epidermidis Phages Transduce Antimicrobial Resistance Plasmids and Mobilize Chromosomal Islands.mSphere · 2021Article
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5 authors.
Funding
Abstract
In recent decades, the notorious pathogen Staphylococcus aureus has become progressively more contagious, more virulent, and more resistant to antibiotics. This implies a rather dynamic evolutionary capability, representing a remarkable level of genomic plasticity, most probably maintained by horizontal gene transfer. Here we report that the staphylococcal pathogenicity islands have a dual role in gene transfer: they not only mediate their own transfer, but they can independently direct the transfer of unlinked chromosomal segments containing virulence genes. While transfer of the island itself requires specific helper phages, transfer of unlinked chromosomal segments does not, so potentially any pac-type phage will serve. These results reveal that SaPIs can increase the horizontal exchange of accessory genes associated with disease and may shape pathogen genomes beyond the confines of their attachment sites.
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