Evidence map›Paper›PMID 25497980›Full record

ArticleJournal of clinical epidemiology2015

Statistical approaches to harmonize data on cognitive measures in systematic reviews are rarely reported.

Lauren E Griffith, Edwin van den Heuvel, Isabel Fortier, Nazmul Sohel, Scott M Hofer, Hélène Payette, Christina Wolfson, Sylvie Belleville, Meghan Kenny, Dany Doiron and 1 more

Abstract read
In one paragraph

Article in Journal of clinical epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Evidence triangulation in health research.European journal of epidemiology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Data resource profile: the virtual international care homes trials archive (VICHTA).International journal of population data science · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lauren E GriffithDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Edwin van den HeuvelDepartment of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands.
Isabel FortierResearch Institute of the McGill University Health Centre and Department of Medicine, McGill University, Montreal, Canada.
Nazmul SohelDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Scott M HoferDepartment of Psychology, University of Victoria, Victoria, British Columbia, Canada.
Hélène PayetteResearch Center on Aging, Health & Social Services Center-University Institute of Geriatrics of Sherbrooke and Department of Community Health and Sciences, University of Sherbrooke, Sherbrooke, Canada.
Christina WolfsonResearch Institute of the McGill University Health Centre and Department of Epidemiology and Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Sylvie BellevilleResearch Center, Institut Universitaire de Gériatrie de Montréal and Department of Psychology, Université de Montréal, Montreal, Canada.
Meghan KennyDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Dany DoironResearch Institute of the McGill University Health Centre and Department of Medicine, McGill University, Montreal, Canada.
Parminder RainaDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. Electronic address: praina@mcmaster.ca.

Funding

Study Coordination and Measurement CoreP01AG043362 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI HOFER, SCOTT M. · 2013 to 2017
$7.8M
Canadian Institutes of Health ResearchNIA NIH HHS P01 AG043362NIA NIH HHS P01AG043362
6 · The paper itself

Abstract

objectivesTo identify statistical methods for harmonization, the procedures aimed at achieving the comparability of previously collected data, which could be used in the context of summary data and individual participant data meta-analysis of cognitive measures. STUDY DESIGN AND

settingEnvironmental scan methods were used to conduct two reviews to identify (1) studies that quantitatively combined data on cognition and (2) general literature on statistical methods for data harmonization. Search results were rapidly screened to identify articles of relevance.

resultsAll 33 meta-analyses combining cognition measures either restricted their analyses to a subset of studies using a common measure or combined standardized effect sizes across studies; none reported their harmonization steps before producing summary effects. In the second scan, three general classes of statistical harmonization models were identified (1) standardization methods, (2) latent variable models, and (3) multiple imputation models; few publications compared methods.

conclusionAlthough it is an implicit part of conducting a meta-analysis or pooled analysis, the methods used to assess inferential equivalence of complex constructs are rarely reported or discussed. Progress in this area will be supported by guidelines for the conduct and reporting of the data harmonization and integration and by evaluating and developing statistical approaches to harmonization.

Indexed as

Data Interpretation, StatisticalReview Literature as TopicCognition DisordersEvidence-Based PracticeHumansMeta-Analysis as TopicResearch DesignCognitionCombinationData poolingHarmonizationIndividual participant dataMeta-analysisTransformation

Identifiers

PMID25497980
PMCPMC4685455

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.